Electromagnetic navigation bronchoscopy for lung nodule evaluation: Patient selection, diagnostic variables and safety

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Electromagnetic navigation bronchoscopy for lung nodule evaluation : Patient selection, diagnostic variables and safety. / Andersen, Frank D; Degn, Kristine B; Riis Rasmussen, Torben.

I: The Clinical Respiratory Journal, Bind 14, Nr. 6, 06.2020, s. 557-563.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{199e2c41bd3d45ad985864df8eafa8a1,
title = "Electromagnetic navigation bronchoscopy for lung nodule evaluation: Patient selection, diagnostic variables and safety",
abstract = "BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) is a relatively new technique to diagnose pulmonary lesions in patients with reduced lung function. Several parameters have been shown to affect diagnostic yield including patient selection. We performed a prospective registration of data on one hundred patients who consecutively underwent electromagnetic navigation bronchoscopy. Selection criteria, patient characteristics, lesion size, distance to pleura, location of the lesion and presence of bronchus sign on computed tomography were registered.METHODS: Navigation was performed using the superDimension hardware and software system. Patients were referred to ENB from a multidisciplinary team conference. We did not use fluoroscopy, endobronchial ultrasound equipment, rapid onsite evaluation or general anesthesia during the procedure. All patients in whom no malignant diagnose was found were subsequently followed for two years in order to verify a benign nature of the pulmonary lesion.RESULTS: One hundred and nine ENB procedures were performed between September 2009 and November 2014. Overall diagnostic yield was 68%. Twenty seven of 49 malignant tumors were found by ENB leading to a sensitivity for malignancy of 55%. The sensitivity for malignancy was significantly higher for lesions in the upper and middle lobes compared to the lower lobes (P = 0.01). Lesions size, distance to pleura and presence of bronchus sign did not affect sensitivity.CONCLUSION: ENB is a safe diagnostic procedure in an everyday setting with an acceptable diagnostic yield even without addition of supportive diagnostic methods and offers a possibility to diagnose pulmonary nodules in patients for whom other diagnostic procedures are too hazardous or have proven unsuccessful.",
keywords = "bronchoscopy, electromagnetic, lung cancer, navigation, pulmonary nodule",
author = "Andersen, {Frank D} and Degn, {Kristine B} and {Riis Rasmussen}, Torben",
note = "{\textcopyright} 2020 John Wiley & Sons Ltd.",
year = "2020",
month = jun,
doi = "10.1111/crj.13168",
language = "English",
volume = "14",
pages = "557--563",
journal = "Clinical Respiratory Journal",
issn = "1752-6981",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Electromagnetic navigation bronchoscopy for lung nodule evaluation

T2 - Patient selection, diagnostic variables and safety

AU - Andersen, Frank D

AU - Degn, Kristine B

AU - Riis Rasmussen, Torben

N1 - © 2020 John Wiley & Sons Ltd.

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) is a relatively new technique to diagnose pulmonary lesions in patients with reduced lung function. Several parameters have been shown to affect diagnostic yield including patient selection. We performed a prospective registration of data on one hundred patients who consecutively underwent electromagnetic navigation bronchoscopy. Selection criteria, patient characteristics, lesion size, distance to pleura, location of the lesion and presence of bronchus sign on computed tomography were registered.METHODS: Navigation was performed using the superDimension hardware and software system. Patients were referred to ENB from a multidisciplinary team conference. We did not use fluoroscopy, endobronchial ultrasound equipment, rapid onsite evaluation or general anesthesia during the procedure. All patients in whom no malignant diagnose was found were subsequently followed for two years in order to verify a benign nature of the pulmonary lesion.RESULTS: One hundred and nine ENB procedures were performed between September 2009 and November 2014. Overall diagnostic yield was 68%. Twenty seven of 49 malignant tumors were found by ENB leading to a sensitivity for malignancy of 55%. The sensitivity for malignancy was significantly higher for lesions in the upper and middle lobes compared to the lower lobes (P = 0.01). Lesions size, distance to pleura and presence of bronchus sign did not affect sensitivity.CONCLUSION: ENB is a safe diagnostic procedure in an everyday setting with an acceptable diagnostic yield even without addition of supportive diagnostic methods and offers a possibility to diagnose pulmonary nodules in patients for whom other diagnostic procedures are too hazardous or have proven unsuccessful.

AB - BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) is a relatively new technique to diagnose pulmonary lesions in patients with reduced lung function. Several parameters have been shown to affect diagnostic yield including patient selection. We performed a prospective registration of data on one hundred patients who consecutively underwent electromagnetic navigation bronchoscopy. Selection criteria, patient characteristics, lesion size, distance to pleura, location of the lesion and presence of bronchus sign on computed tomography were registered.METHODS: Navigation was performed using the superDimension hardware and software system. Patients were referred to ENB from a multidisciplinary team conference. We did not use fluoroscopy, endobronchial ultrasound equipment, rapid onsite evaluation or general anesthesia during the procedure. All patients in whom no malignant diagnose was found were subsequently followed for two years in order to verify a benign nature of the pulmonary lesion.RESULTS: One hundred and nine ENB procedures were performed between September 2009 and November 2014. Overall diagnostic yield was 68%. Twenty seven of 49 malignant tumors were found by ENB leading to a sensitivity for malignancy of 55%. The sensitivity for malignancy was significantly higher for lesions in the upper and middle lobes compared to the lower lobes (P = 0.01). Lesions size, distance to pleura and presence of bronchus sign did not affect sensitivity.CONCLUSION: ENB is a safe diagnostic procedure in an everyday setting with an acceptable diagnostic yield even without addition of supportive diagnostic methods and offers a possibility to diagnose pulmonary nodules in patients for whom other diagnostic procedures are too hazardous or have proven unsuccessful.

KW - bronchoscopy

KW - electromagnetic

KW - lung cancer

KW - navigation

KW - pulmonary nodule

UR - http://www.scopus.com/inward/record.url?scp=85086011976&partnerID=8YFLogxK

U2 - 10.1111/crj.13168

DO - 10.1111/crj.13168

M3 - Journal article

C2 - 32052591

VL - 14

SP - 557

EP - 563

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 6

ER -