Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest

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Electrolyte profiles with induced hypothermia : A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest. / Kirkegaard, Hans; Grejs, Anders M.; Gudbjerg, Simon et al.

I: Acta Anaesthesiologica Scandinavica, Bind 66, Nr. 5, 05.2022, s. 615-624.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kirkegaard, H, Grejs, AM, Gudbjerg, S, Duez, C, Jeppesen, A, Hassager, C, Laitio, T, Storm, C, Taccone, FS, Skrifvars, MB & Søreide, E 2022, 'Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest', Acta Anaesthesiologica Scandinavica, bind 66, nr. 5, s. 615-624. https://doi.org/10.1111/aas.14053

APA

Kirkegaard, H., Grejs, A. M., Gudbjerg, S., Duez, C., Jeppesen, A., Hassager, C., Laitio, T., Storm, C., Taccone, F. S., Skrifvars, M. B., & Søreide, E. (2022). Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest. Acta Anaesthesiologica Scandinavica, 66(5), 615-624. https://doi.org/10.1111/aas.14053

CBE

Kirkegaard H, Grejs AM, Gudbjerg S, Duez C, Jeppesen A, Hassager C, Laitio T, Storm C, Taccone FS, Skrifvars MB, et al. 2022. Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest. Acta Anaesthesiologica Scandinavica. 66(5):615-624. https://doi.org/10.1111/aas.14053

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@article{d227ae9934d54a81805eb9f0e5e7a475,
title = "Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest",
abstract = "Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM. Methods: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Over a three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24-h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed-model multivariate analysis of variance with repeated measurements. Results: On admission, mean ± SD sodium concentration was 138 ± 3.5 mmol/l, which increased slightly but significantly (p <.05) during the first 24 h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1–1.2) mmol/l during the first 24 h (p <.05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8–1.2) mmol/l (p <.05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (p <.05). Median 24-h diuresis results on days one and two were 2198 and 2048 ml respectively, and the electrolyte excretion mostly stayed low in the reference interval. Conclusions: Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM{\textquoteright}s different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.",
author = "Hans Kirkegaard and Grejs, {Anders M.} and Simon Gudbjerg and Christophe Duez and Anni Jeppesen and Christian Hassager and Timo Laitio and Christian Storm and Taccone, {Fabio Silvio} and Skrifvars, {Markus B.} and Eldar S{\o}reide",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.",
year = "2022",
month = may,
doi = "10.1111/aas.14053",
language = "English",
volume = "66",
pages = "615--624",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Electrolyte profiles with induced hypothermia

T2 - A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest

AU - Kirkegaard, Hans

AU - Grejs, Anders M.

AU - Gudbjerg, Simon

AU - Duez, Christophe

AU - Jeppesen, Anni

AU - Hassager, Christian

AU - Laitio, Timo

AU - Storm, Christian

AU - Taccone, Fabio Silvio

AU - Skrifvars, Markus B.

AU - Søreide, Eldar

N1 - Publisher Copyright: © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

PY - 2022/5

Y1 - 2022/5

N2 - Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM. Methods: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Over a three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24-h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed-model multivariate analysis of variance with repeated measurements. Results: On admission, mean ± SD sodium concentration was 138 ± 3.5 mmol/l, which increased slightly but significantly (p <.05) during the first 24 h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1–1.2) mmol/l during the first 24 h (p <.05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8–1.2) mmol/l (p <.05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (p <.05). Median 24-h diuresis results on days one and two were 2198 and 2048 ml respectively, and the electrolyte excretion mostly stayed low in the reference interval. Conclusions: Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM’s different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.

AB - Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM. Methods: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Over a three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24-h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed-model multivariate analysis of variance with repeated measurements. Results: On admission, mean ± SD sodium concentration was 138 ± 3.5 mmol/l, which increased slightly but significantly (p <.05) during the first 24 h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1–1.2) mmol/l during the first 24 h (p <.05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8–1.2) mmol/l (p <.05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (p <.05). Median 24-h diuresis results on days one and two were 2198 and 2048 ml respectively, and the electrolyte excretion mostly stayed low in the reference interval. Conclusions: Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM’s different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.

UR - http://www.scopus.com/inward/record.url?scp=85127240080&partnerID=8YFLogxK

U2 - 10.1111/aas.14053

DO - 10.1111/aas.14053

M3 - Journal article

C2 - 35218019

AN - SCOPUS:85127240080

VL - 66

SP - 615

EP - 624

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 5

ER -