Electrocatalytic Discrimination between Dopamine and Norepinephrine at Graphite and Basal Plane HOPG Electrodes

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Electrocatalytic Discrimination between Dopamine and Norepinephrine at Graphite and Basal Plane HOPG Electrodes. / Álvarez-Martos, Isabel; Ferapontova, Elena E.

I: Electroanalysis, Bind 30, Nr. 6, 01.06.2018, s. 1082-1090.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{64d1f7e756cd4713bd4b8ec0b1ee3918,
title = "Electrocatalytic Discrimination between Dopamine and Norepinephrine at Graphite and Basal Plane HOPG Electrodes",
abstract = "Understanding the regulatory mechanisms of neurotransmission is impossible without in vivo monitoring of neurotransmitters{\textquoteright} (NTs) transformation in the brain, and that can be performed by a variety of electrochemical methods. Close redox potentials of such NTs as catecholamines, however, impede their specific analysis in systems where they do co-exist. Here, we studied the kinetics of dopamine and norepinephrine redox transformations on glassy carbon, micro-structured spectroscopic graphite, and basal plane HOPG electrodes. We showed that in contrast to the “positive electrocatalysis” on porous microstructured graphite electrodes, “negative electrocatalysis” at the HOPG electrodes, displayed through slowing down of the reaction rate, allowed a ca. 0.1 V separation between dopamine and norepinephrine oxidations and individual detection of dopamine in the artificial cerebrospinal fluid. Dopamine could be detected within the 50 nM to 4 μM range with no interference from excesses of norepinephrine and ascorbic acid. The results suggest a new approach for design of the electrodes for specific analysis of dopamine in mixtures of structurally related NTs.",
keywords = "Dopamine, Electroanalysis, Highly ordered pyrolytic graphite (HOPG), Norepinephrine, Spectroscopic graphite",
author = "Isabel {\'A}lvarez-Martos and Ferapontova, {Elena E.}",
year = "2018",
month = jun,
day = "1",
doi = "10.1002/elan.201700837",
language = "English",
volume = "30",
pages = "1082--1090",
journal = "Electroanalysis",
issn = "1040-0397",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "6",

}

RIS

TY - JOUR

T1 - Electrocatalytic Discrimination between Dopamine and Norepinephrine at Graphite and Basal Plane HOPG Electrodes

AU - Álvarez-Martos, Isabel

AU - Ferapontova, Elena E.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Understanding the regulatory mechanisms of neurotransmission is impossible without in vivo monitoring of neurotransmitters’ (NTs) transformation in the brain, and that can be performed by a variety of electrochemical methods. Close redox potentials of such NTs as catecholamines, however, impede their specific analysis in systems where they do co-exist. Here, we studied the kinetics of dopamine and norepinephrine redox transformations on glassy carbon, micro-structured spectroscopic graphite, and basal plane HOPG electrodes. We showed that in contrast to the “positive electrocatalysis” on porous microstructured graphite electrodes, “negative electrocatalysis” at the HOPG electrodes, displayed through slowing down of the reaction rate, allowed a ca. 0.1 V separation between dopamine and norepinephrine oxidations and individual detection of dopamine in the artificial cerebrospinal fluid. Dopamine could be detected within the 50 nM to 4 μM range with no interference from excesses of norepinephrine and ascorbic acid. The results suggest a new approach for design of the electrodes for specific analysis of dopamine in mixtures of structurally related NTs.

AB - Understanding the regulatory mechanisms of neurotransmission is impossible without in vivo monitoring of neurotransmitters’ (NTs) transformation in the brain, and that can be performed by a variety of electrochemical methods. Close redox potentials of such NTs as catecholamines, however, impede their specific analysis in systems where they do co-exist. Here, we studied the kinetics of dopamine and norepinephrine redox transformations on glassy carbon, micro-structured spectroscopic graphite, and basal plane HOPG electrodes. We showed that in contrast to the “positive electrocatalysis” on porous microstructured graphite electrodes, “negative electrocatalysis” at the HOPG electrodes, displayed through slowing down of the reaction rate, allowed a ca. 0.1 V separation between dopamine and norepinephrine oxidations and individual detection of dopamine in the artificial cerebrospinal fluid. Dopamine could be detected within the 50 nM to 4 μM range with no interference from excesses of norepinephrine and ascorbic acid. The results suggest a new approach for design of the electrodes for specific analysis of dopamine in mixtures of structurally related NTs.

KW - Dopamine

KW - Electroanalysis

KW - Highly ordered pyrolytic graphite (HOPG)

KW - Norepinephrine

KW - Spectroscopic graphite

U2 - 10.1002/elan.201700837

DO - 10.1002/elan.201700837

M3 - Journal article

AN - SCOPUS:85048568961

VL - 30

SP - 1082

EP - 1090

JO - Electroanalysis

JF - Electroanalysis

SN - 1040-0397

IS - 6

ER -