Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-Based Nanomaterials

Zhongyang Zhang; Lasse Hyldgaard Klausen; Menglin Chen; Mingdong Dong

doi:10.1002/smll.201801983

Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-Based Nanomaterials

Zhongyang Zhang, Lasse Hyldgaard Klausen, Menglin Chen, Mingdong Dong^*

^*Corresponding author af dette arbejde

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

One of the major issues in tissue engineering is constructing a functional scaffold to support cell growth and also provide proper synergistic guidance cues. Graphene-based nanomaterials have emerged as biocompatible and electroactive scaffolds for neurogenesis and myogenesis, due to their excellent tunable chemical, physical, and mechanical properties. This review first assesses the recent investigations focusing on the fabrication and applications of graphene-based nanomaterials for neurogenesis and myogenesis, in the form of either 2D films, 3D scaffolds, or composite architectures. Besides, because of their outstanding electrical properties, graphene family materials are particularly suitable for designing electroactive scaffolds that could provide proper electrical stimulation (i.e., electrical or photo stimuli) to promote the regeneration of excitable neurons and muscle cells. Therefore, the effects and mechanism of electrical and/or photo stimulations on neurogenesis and myogenesis are followed. Furthermore, studies on their biocompatibilities and toxicities especially to neural and muscle cells are evaluated. Finally, the future challenges and perspectives in facilitating the development of clinical translation of graphene-family nanomaterials in treating neurodegenerative and muscle diseases are discussed.

Originalsprog	Engelsk
Artikelnummer	1801983
Tidsskrift	Small
Vol/bind	14
Nummer	48
ISSN	1613-6810
DOI	https://doi.org/10.1002/smll.201801983
Status	Udgivet - 28 nov. 2018

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10.1002/smll.201801983

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title = "Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-Based Nanomaterials",

abstract = "One of the major issues in tissue engineering is constructing a functional scaffold to support cell growth and also provide proper synergistic guidance cues. Graphene-based nanomaterials have emerged as biocompatible and electroactive scaffolds for neurogenesis and myogenesis, due to their excellent tunable chemical, physical, and mechanical properties. This review first assesses the recent investigations focusing on the fabrication and applications of graphene-based nanomaterials for neurogenesis and myogenesis, in the form of either 2D films, 3D scaffolds, or composite architectures. Besides, because of their outstanding electrical properties, graphene family materials are particularly suitable for designing electroactive scaffolds that could provide proper electrical stimulation (i.e., electrical or photo stimuli) to promote the regeneration of excitable neurons and muscle cells. Therefore, the effects and mechanism of electrical and/or photo stimulations on neurogenesis and myogenesis are followed. Furthermore, studies on their biocompatibilities and toxicities especially to neural and muscle cells are evaluated. Finally, the future challenges and perspectives in facilitating the development of clinical translation of graphene-family nanomaterials in treating neurodegenerative and muscle diseases are discussed.",

keywords = "electrical stimulation, electroactive scaffolds, graphene, myogenesis, neurogenesis",

author = "Zhongyang Zhang and Klausen, {Lasse Hyldgaard} and Menglin Chen and Mingdong Dong",

year = "2018",

month = nov,

day = "28",

doi = "10.1002/smll.201801983",

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issn = "1613-6810",

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TY - JOUR

T1 - Electroactive Scaffolds for Neurogenesis and Myogenesis

T2 - Graphene-Based Nanomaterials

AU - Zhang, Zhongyang

AU - Klausen, Lasse Hyldgaard

AU - Chen, Menglin

AU - Dong, Mingdong

PY - 2018/11/28

Y1 - 2018/11/28

N2 - One of the major issues in tissue engineering is constructing a functional scaffold to support cell growth and also provide proper synergistic guidance cues. Graphene-based nanomaterials have emerged as biocompatible and electroactive scaffolds for neurogenesis and myogenesis, due to their excellent tunable chemical, physical, and mechanical properties. This review first assesses the recent investigations focusing on the fabrication and applications of graphene-based nanomaterials for neurogenesis and myogenesis, in the form of either 2D films, 3D scaffolds, or composite architectures. Besides, because of their outstanding electrical properties, graphene family materials are particularly suitable for designing electroactive scaffolds that could provide proper electrical stimulation (i.e., electrical or photo stimuli) to promote the regeneration of excitable neurons and muscle cells. Therefore, the effects and mechanism of electrical and/or photo stimulations on neurogenesis and myogenesis are followed. Furthermore, studies on their biocompatibilities and toxicities especially to neural and muscle cells are evaluated. Finally, the future challenges and perspectives in facilitating the development of clinical translation of graphene-family nanomaterials in treating neurodegenerative and muscle diseases are discussed.

AB - One of the major issues in tissue engineering is constructing a functional scaffold to support cell growth and also provide proper synergistic guidance cues. Graphene-based nanomaterials have emerged as biocompatible and electroactive scaffolds for neurogenesis and myogenesis, due to their excellent tunable chemical, physical, and mechanical properties. This review first assesses the recent investigations focusing on the fabrication and applications of graphene-based nanomaterials for neurogenesis and myogenesis, in the form of either 2D films, 3D scaffolds, or composite architectures. Besides, because of their outstanding electrical properties, graphene family materials are particularly suitable for designing electroactive scaffolds that could provide proper electrical stimulation (i.e., electrical or photo stimuli) to promote the regeneration of excitable neurons and muscle cells. Therefore, the effects and mechanism of electrical and/or photo stimulations on neurogenesis and myogenesis are followed. Furthermore, studies on their biocompatibilities and toxicities especially to neural and muscle cells are evaluated. Finally, the future challenges and perspectives in facilitating the development of clinical translation of graphene-family nanomaterials in treating neurodegenerative and muscle diseases are discussed.

KW - electrical stimulation

KW - electroactive scaffolds

KW - graphene

KW - myogenesis

KW - neurogenesis

U2 - 10.1002/smll.201801983

DO - 10.1002/smll.201801983

M3 - Journal article

C2 - 30264534

AN - SCOPUS:85053923429

SN - 1613-6810

VL - 14

JO - Small

JF - Small

IS - 48

M1 - 1801983

ER -

Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-Based Nanomaterials

Abstract

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