Efficacy of FODMAP Elimination and Subsequent Blinded Placebo‐Controlled Provocations in a Randomised Controlled Study in Patients with Ulcerative Colitis in Remission and Symptoms of Irritable Bowel Syndrome: A Feasibility Study

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DOI

  • Dorte Melgaard, North Denmark Regional Hospital, Aalborg Universitet
  • ,
  • Jeanette Sørensen, North Denmark Regional Hospital
  • ,
  • Johannes Riis, North Denmark Regional Hospital
  • ,
  • Tine S. Ovesen, North Denmark Regional Hospital
  • ,
  • Peter Leutscher, North Denmark Regional Hospital, Aalborg Universitet
  • ,
  • Suzette Sørensen, North Denmark Regional Hospital, Aalborg Universitet
  • ,
  • Julie K. Knudsen, North Denmark Regional Hospital
  • ,
  • Caspar Bundgaard‐nielsen, North Denmark Regional Hospital
  • ,
  • Jeanette Ejstrup, North Denmark Regional Hospital
  • ,
  • Ann Maria Jensen, North Denmark Regional Hospital
  • ,
  • Mette Borre
  • Anne L. Krarup, Aalborg Universitet, North Denmark Regional Hospital

Background: Patients with inflammatory bowel disease (IBD) and symptoms of irritable bowel syndrome (IBS) may be intolerant to fermentable carbohydrates (FODMAPs). The aim of this study was to test the feasibility of eliminating and subsequently reintroducing FODMAPs in patients with IBS symptoms as part of the IBD manifestation and to compare the severity of IBS symptoms and pain, bloating and quality of life (QoL). Methods: An eight‐week randomised open-label FODMAP elimination with double‐blinded, crossover provocations of FODMAP and placebo. Diet patients were on a low‐FODMAP diet for eight weeks with blinded two‐week provocations after two and six weeks. Questionnaires, blood and stool samples were collected. Results: Patient enrolment was challenging. Nineteen participants were included in the study. Eliminating low FODMAP for two weeks resulted in significant decreases in pain and bloating scores (p < 0.003), whereas there were no statistical differences in pain scores between diet patients and controls. Pain and bloating scores increased, returning to baseline levels after two weeks of double‐blinded provocations with placebo, (p > 0.05). Conclusions: The results document the possibility of performing a randomised controlled study following the gold standard for testing food intolerance with blinding of the Low FODMAP diet. Recruitment of participants was challenging.

OriginalsprogEngelsk
Artikelnummer1296
TidsskriftNutrients
Vol/bind14
Nummer6
ISSN2072-6643
DOI
StatusUdgivet - mar. 2022

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