Aarhus University Seal / Aarhus Universitets segl

Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder. / Wong, Wan wa; Cabral, Joana; Rane, Riddhi; Ly, Ronald; Kringelbach, Morten L.; Feusner, Jamie D.

I: Neuropsychopharmacology, Bind 46, Nr. 11, 10.2021, s. 2030-2038.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Wong, Wan wa ; Cabral, Joana ; Rane, Riddhi ; Ly, Ronald ; Kringelbach, Morten L. ; Feusner, Jamie D. / Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder. I: Neuropsychopharmacology. 2021 ; Bind 46, Nr. 11. s. 2030-2038.

Bibtex

@article{2337db42d3ae447dabe496634f6c2403,
title = "Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder",
abstract = "Body dysmorphic disorder (BDD) is characterized by preoccupations with misperceptions of one{\textquoteright}s physical appearance. Previous neuroimaging studies in BDD have yet to examine dynamic functional connectivity (FC) patterns between brain areas, necessary to capture changes in activity in response to stimuli and task conditions. We used Leading Eigenvector Dynamics Analysis to examine whole-brain dynamic FC from fMRI data during an own-face viewing task in 29 unmedicated adults with BDD with facial concerns and 30 healthy controls. The task involved two parts: (1) unconstrained, naturalistic viewing and (2) holding visual attention in the center of the image, to reduce scanning and fixation on perceived facial flaws. An FC state consisting of bilateral medial orbitofrontal cortex regions occurred significantly less often during the visual attention condition and afterward during the unconstrained face viewing in BDD participants, compared to the first unconstrained face viewing, a pattern that differed from controls. Moreover, the probability of this state during the second unconstrained face viewing was associated with severity of obsessions and compulsions and degree of poor insight in BDD, suggesting its clinical significance. These findings have implications for understanding the pathophysiology of own-face viewing in BDD and how it is affected by modification of viewing patterns, which may have implications for novel perceptual retraining treatment designs.",
author = "Wong, {Wan wa} and Joana Cabral and Riddhi Rane and Ronald Ly and Kringelbach, {Morten L.} and Feusner, {Jamie D.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to American College of Neuropsychopharmacology.",
year = "2021",
month = oct,
doi = "10.1038/s41386-021-01039-w",
language = "English",
volume = "46",
pages = "2030--2038",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder

AU - Wong, Wan wa

AU - Cabral, Joana

AU - Rane, Riddhi

AU - Ly, Ronald

AU - Kringelbach, Morten L.

AU - Feusner, Jamie D.

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to American College of Neuropsychopharmacology.

PY - 2021/10

Y1 - 2021/10

N2 - Body dysmorphic disorder (BDD) is characterized by preoccupations with misperceptions of one’s physical appearance. Previous neuroimaging studies in BDD have yet to examine dynamic functional connectivity (FC) patterns between brain areas, necessary to capture changes in activity in response to stimuli and task conditions. We used Leading Eigenvector Dynamics Analysis to examine whole-brain dynamic FC from fMRI data during an own-face viewing task in 29 unmedicated adults with BDD with facial concerns and 30 healthy controls. The task involved two parts: (1) unconstrained, naturalistic viewing and (2) holding visual attention in the center of the image, to reduce scanning and fixation on perceived facial flaws. An FC state consisting of bilateral medial orbitofrontal cortex regions occurred significantly less often during the visual attention condition and afterward during the unconstrained face viewing in BDD participants, compared to the first unconstrained face viewing, a pattern that differed from controls. Moreover, the probability of this state during the second unconstrained face viewing was associated with severity of obsessions and compulsions and degree of poor insight in BDD, suggesting its clinical significance. These findings have implications for understanding the pathophysiology of own-face viewing in BDD and how it is affected by modification of viewing patterns, which may have implications for novel perceptual retraining treatment designs.

AB - Body dysmorphic disorder (BDD) is characterized by preoccupations with misperceptions of one’s physical appearance. Previous neuroimaging studies in BDD have yet to examine dynamic functional connectivity (FC) patterns between brain areas, necessary to capture changes in activity in response to stimuli and task conditions. We used Leading Eigenvector Dynamics Analysis to examine whole-brain dynamic FC from fMRI data during an own-face viewing task in 29 unmedicated adults with BDD with facial concerns and 30 healthy controls. The task involved two parts: (1) unconstrained, naturalistic viewing and (2) holding visual attention in the center of the image, to reduce scanning and fixation on perceived facial flaws. An FC state consisting of bilateral medial orbitofrontal cortex regions occurred significantly less often during the visual attention condition and afterward during the unconstrained face viewing in BDD participants, compared to the first unconstrained face viewing, a pattern that differed from controls. Moreover, the probability of this state during the second unconstrained face viewing was associated with severity of obsessions and compulsions and degree of poor insight in BDD, suggesting its clinical significance. These findings have implications for understanding the pathophysiology of own-face viewing in BDD and how it is affected by modification of viewing patterns, which may have implications for novel perceptual retraining treatment designs.

UR - http://www.scopus.com/inward/record.url?scp=85106730720&partnerID=8YFLogxK

U2 - 10.1038/s41386-021-01039-w

DO - 10.1038/s41386-021-01039-w

M3 - Journal article

C2 - 34050267

AN - SCOPUS:85106730720

VL - 46

SP - 2030

EP - 2038

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 11

ER -