Effects of Bacillus Calmette-Guérin (BCG) vaccination at birth on T and B lymphocyte subsets: Results from a clinical randomized trial

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  • Nina Marie Birk, Department of Pediatrics, Copenhagen University Hospital, Hvidovre, Kettegårds Allé 30, 2650, Hvidovre, Denmark. ninabirk@dadlnet.dk.
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  • Thomas Nørrelykke Nissen, Department of Pediatrics, Copenhagen University Hospital, Hvidovre, Kettegårds Allé 30, 2650, Hvidovre, Denmark.
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  • Jesper Kjærgaard, The Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
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  • Hans Jacob Hartling, Department of Infectious Diseases, Rigshospitalet, The National University Hospital, Blegdamsvej 9, 2100 Kbh Ø Copenhagen, Denmark.
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  • Lisbeth Marianne Thøstesen
  • Poul-Erik Kofoed, Department of Pediatrics, Kolding Hospital, Sygehusvej 24, 6000, Kolding, Denmark.
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  • Lone Graff Stensballe, The Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
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  • Andreas Andersen
  • Ole Pryds, Department of Pediatrics, Copenhagen University Hospital, Hvidovre, Kettegårds Allé 30, 2650, Hvidovre, Denmark.
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  • Mihai G Netea, Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein 8, 6525 GA, Nijmegen, The Netherlands.
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  • Christine Stabell Benn, Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, DK-5000 Odense, Denmark. Electronic address: hjn@ssi.dk.
  • ,
  • Susanne Dam Nielsen
  • Dorthe Lisbeth Jeppesen, Department of Pediatrics, Copenhagen University Hospital, Hvidovre, Kettegårds Allé 30, 2650, Hvidovre, Denmark.

The Bacillus Calmette-Guérin vaccine (BCG) has been associated with beneficial non-specific effects (NSEs) on infant health. Within a randomized trial on the effect of neonatal BCG on overall health, we investigated the possible immunological impact of neonatal BCG vaccination on lymphocyte subsets, determined by flow cytometry. In 118 infants blood samples were obtained 4 (±2) days post randomization to BCG vaccination or no intervention, and at 3 and 13 months of age. No effects of BCG were found at 4 days. However, BCG increased proportions of effector memory cells at 3 months (Geometric mean ratio (GMR) 1.62, 95% confidence interval (CI) (1.20-2.21), p = 0.002 for CD4+ T cells and GMR 1.69, 95% CI (1.06-2.70), p = 0.03 for CD8+ T cells), and reduced proportions of late differentiated CD4+ T cells (GMR = 0.62, 95% CI (0.38-1.00), p = 0.05) and apoptotic CD4+ T cells at 13 months (GMR = 0.55, 95% CI (0.32-0.92), p = 0.03). In conclusion, limited overall impact of neonatal BCG vaccination on lymphocyte subsets was found in healthy Danish infants within the first 13 months of life. This is in line with the limited clinical effects of BCG observed in our setting.

OriginalsprogEngelsk
Artikelnummer12398
TidsskriftScientific Reports
Vol/bind7
Nummer1
ISSN2045-2322
DOI
StatusUdgivet - 29 sep. 2017
Eksternt udgivetJa

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