Effect of weight reductions on estimated kidney function: Post-hoc analysis of two randomized trials

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Bernt Johan von Scholten, Steno Diabetes Center
  • ,
  • Melanie J. Davies, Leicester University
  • ,
  • Frederik Persson, Steno Diabetes Center
  • ,
  • Tine W. Hansen, Steno Diabetes Center
  • ,
  • Sten Madsbad, Hvidovre Universitets Hospital, Hvidovre
  • ,
  • Lars Endahl, Novo Nordisk AS
  • ,
  • Cecilie H. Jepsen, Novo Nordisk AS
  • ,
  • Peter Rossing, Steno Diabetes Center, Københavns Universitet

Aims Weight loss-induced serum creatinine reduction may increase creatinine-based estimated glomerular filtration rate (eGFR) producing incorrect estimates of kidney function. We investigated whether weight changes in the SCALE program with liraglutide 3.0 mg were associated with changes in serum creatinine. Methods Post hoc analysis of two 56-week, randomized, double-blind trials: SCALE Obesity and Prediabetes (n = 3731, without type 2 diabetes [T2D], randomized [2:1] to liraglutide 3.0 mg [n = 2487] or placebo [n = 1244]); SCALE Diabetes (n = 846 with T2D, randomized [2:1:1] to liraglutide 3.0 mg [n = 423], 1.8 mg [n = 211, excluded from this analysis] or placebo [n = 212]). NCT01272219/NCT01272232. Results In SCALE Obesity and Prediabetes, mean (± SD) weight loss (baseline to week 56) with liraglutide was 8.0 ± 6.7% (2.6 ± 6.9% with placebo); baseline creatinine with liraglutide was 76 ± 15 μmol/L and 74 ± 15 μmol/L after 56 weeks (similar across treatment groups). In SCALE Diabetes, weight loss with liraglutide was 5.9 ± 5.5% (2.0 ± 4.3% with placebo); baseline creatinine was 79 ± 19 μmol/L (77 ± 16 μmol/L, placebo) and 79 ± 20 μmol/L after 56 weeks (76 ± 15 μmol/L, placebo). No association between changes in weight and changes in serum creatinine was observed (P ≥ 0.05, both trials, all tests). Conclusions Moderate gradual body weight reductions observed in the SCALE program were not associated with changes in serum creatinine.

OriginalsprogEngelsk
TidsskriftJournal of Diabetes and its Complications
Vol/bind31
Nummer7
Sider (fra-til)1164-1168
Antal sider5
ISSN1056-8727
DOI
StatusUdgivet - jul. 2017

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