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Effect of Repetitive Transcranial Magnetic Stimulation on Altered Perception of One´s Own Face. / Kothari, Simple F.; Dagsdóttir, Lilja Kristin; Kothari, Mohit et al.
I: Brain Stimulation, Bind 13, Nr. 3, 05.2020, s. 554-561.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Effect of Repetitive Transcranial Magnetic Stimulation on Altered Perception of One´s Own Face
AU - Kothari, Simple F.
AU - Dagsdóttir, Lilja Kristin
AU - Kothari, Mohit
AU - Blicher, Jakob
AU - Kumar, Abhishek
AU - Buchholtz, Poul Erik
AU - Ashkanian, Mahmoud
AU - Svensson, Peter
PY - 2020/5
Y1 - 2020/5
N2 - BackgroundChronic orofacial pain (COP) patients often perceive the painful face area as “swollen” without clinical signs; such self-reported illusions of the face are termed perceptual distortion (PD). The pathophysiological mechanisms underlying PD remain elusive.ObjectiveTo test the neuromodulatory effect of repetitive transcranial magnetic stimulation (rTMS) on PD in healthy individuals, to gain insight into the cortical mechanisms underlying PD.MethodsPD was induced experimentally by injections of local anesthetic (LA) around the infraorbital nerve and measured as perceived size changes of the affected area. Participants were randomly allocated to inhibitory rTMS (n=26) or sham rTMS (n=26) group. The participants rated PD at baseline, 6 min after LA, immediately, 20 and 40 min after rTMS. The rTMS (inhibitory and sham) was applied to face (lip) representation area of primary somatosensory cortex (SI) as an intervention at 10 min after the LA, when the magnitude of PD is large. As inhibitory rTMS, continuous theta-burst stimulation paradigm (50 Hz) for 40s was employed to inhibit cortical activity.ResultsWe demonstrated a significant decrease in the magnitude of PD immediately and 20 min after the application of inhibitory rTMS compared with sham rTMS (P<0.006). In two control experiments, we also showed that peripheral muscle stimulation and stimulation of a cortical region other than the lip representation area had no effect on the magnitude of the PD.ConclusionsInhibitory rTMS applied to a somatotopical-relevant cortical region modulates PD of the face in healthy individuals and could potentially have therapeutic implications for COP patients.
AB - BackgroundChronic orofacial pain (COP) patients often perceive the painful face area as “swollen” without clinical signs; such self-reported illusions of the face are termed perceptual distortion (PD). The pathophysiological mechanisms underlying PD remain elusive.ObjectiveTo test the neuromodulatory effect of repetitive transcranial magnetic stimulation (rTMS) on PD in healthy individuals, to gain insight into the cortical mechanisms underlying PD.MethodsPD was induced experimentally by injections of local anesthetic (LA) around the infraorbital nerve and measured as perceived size changes of the affected area. Participants were randomly allocated to inhibitory rTMS (n=26) or sham rTMS (n=26) group. The participants rated PD at baseline, 6 min after LA, immediately, 20 and 40 min after rTMS. The rTMS (inhibitory and sham) was applied to face (lip) representation area of primary somatosensory cortex (SI) as an intervention at 10 min after the LA, when the magnitude of PD is large. As inhibitory rTMS, continuous theta-burst stimulation paradigm (50 Hz) for 40s was employed to inhibit cortical activity.ResultsWe demonstrated a significant decrease in the magnitude of PD immediately and 20 min after the application of inhibitory rTMS compared with sham rTMS (P<0.006). In two control experiments, we also showed that peripheral muscle stimulation and stimulation of a cortical region other than the lip representation area had no effect on the magnitude of the PD.ConclusionsInhibitory rTMS applied to a somatotopical-relevant cortical region modulates PD of the face in healthy individuals and could potentially have therapeutic implications for COP patients.
KW - Local anesthesia
KW - Orofacial pain
KW - Perceptual distortion of face
KW - Primary somatosensory cortex
KW - Repetitive transcranial magnetic stimulation
KW - Theta-burst stimulation
UR - http://www.scopus.com/inward/record.url?scp=85078458099&partnerID=8YFLogxK
U2 - 10.1016/j.brs.2020.01.001
DO - 10.1016/j.brs.2020.01.001
M3 - Journal article
C2 - 32289676
VL - 13
SP - 554
EP - 561
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 3
ER -