Effect of Mindfulness-Based Stress Reduction (MBSR) on dehydroepiandrosterone-sulfate (DHEAS) in adults with self-reported stress. A randomized trial

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Effect of Mindfulness-Based Stress Reduction (MBSR) on dehydroepiandrosterone-sulfate (DHEAS) in adults with self-reported stress. A randomized trial. / Jørgensen, Maja Arena; Pallesen, Karen Johanne; Fjorback, Lone Overby et al.

I: Clinical and Translational Science, Bind 14, Nr. 6, 11.2021, s. 2360-2369.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{3c37d0952d6c4c27889ad435dd68c737,
title = "Effect of Mindfulness-Based Stress Reduction (MBSR) on dehydroepiandrosterone-sulfate (DHEAS) in adults with self-reported stress. A randomized trial",
abstract = "Long-term stress can lead to long-term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone-sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program 'Mindfulness-Based Stress Reduction' (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self-reported stress. The study was a three-armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self-reported stress randomized to either MBSR (n=24), LSR (n=23) or a waiting list (n=24). Blood samples were collected at baseline and at 12 weeks follow-up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both waiting list and LSR. We found a mean effect of 0.70 µmol/L (95%CI 0.18 to 1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95%CI 0.04 to 1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self-reported stress. However, we consider our findings hypothesis-generating and validation by future studies is essential.",
keywords = "ANXIETY, CORTISOL, DHEAS, INTERVENTION, PROGRAM, PSYCHOLOGICAL STRESS, QUALITY-OF-LIFE, RHYTHM, STATE FUNCTIONAL CONNECTIVITY, THERAPY",
author = "J{\o}rgensen, {Maja Arena} and Pallesen, {Karen Johanne} and Fjorback, {Lone Overby} and Lise Juul",
year = "2021",
month = nov,
doi = "10.1111/cts.13100",
language = "English",
volume = "14",
pages = "2360--2369",
journal = "Clinical and Translational Science",
issn = "1752-8054",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of Mindfulness-Based Stress Reduction (MBSR) on dehydroepiandrosterone-sulfate (DHEAS) in adults with self-reported stress. A randomized trial

AU - Jørgensen, Maja Arena

AU - Pallesen, Karen Johanne

AU - Fjorback, Lone Overby

AU - Juul, Lise

PY - 2021/11

Y1 - 2021/11

N2 - Long-term stress can lead to long-term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone-sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program 'Mindfulness-Based Stress Reduction' (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self-reported stress. The study was a three-armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self-reported stress randomized to either MBSR (n=24), LSR (n=23) or a waiting list (n=24). Blood samples were collected at baseline and at 12 weeks follow-up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both waiting list and LSR. We found a mean effect of 0.70 µmol/L (95%CI 0.18 to 1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95%CI 0.04 to 1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self-reported stress. However, we consider our findings hypothesis-generating and validation by future studies is essential.

AB - Long-term stress can lead to long-term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone-sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program 'Mindfulness-Based Stress Reduction' (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self-reported stress. The study was a three-armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self-reported stress randomized to either MBSR (n=24), LSR (n=23) or a waiting list (n=24). Blood samples were collected at baseline and at 12 weeks follow-up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both waiting list and LSR. We found a mean effect of 0.70 µmol/L (95%CI 0.18 to 1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95%CI 0.04 to 1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self-reported stress. However, we consider our findings hypothesis-generating and validation by future studies is essential.

KW - ANXIETY

KW - CORTISOL

KW - DHEAS

KW - INTERVENTION

KW - PROGRAM

KW - PSYCHOLOGICAL STRESS

KW - QUALITY-OF-LIFE

KW - RHYTHM

KW - STATE FUNCTIONAL CONNECTIVITY

KW - THERAPY

UR - http://www.scopus.com/inward/record.url?scp=85109369669&partnerID=8YFLogxK

U2 - 10.1111/cts.13100

DO - 10.1111/cts.13100

M3 - Journal article

C2 - 34121351

VL - 14

SP - 2360

EP - 2369

JO - Clinical and Translational Science

JF - Clinical and Translational Science

SN - 1752-8054

IS - 6

ER -