Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles

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Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles. / Matsuzaki, Satoshi; Shimada, Akiko; Tanaka, Junko; Kothari, Mohit; Castrillon, Eduardo; Iida, Takashi; Svensson, Peter.

I: The Journal of Clinical Sleep Medicine, Bind 17, Nr. 9, 09.2021, s. 1805-1813.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Matsuzaki, S, Shimada, A, Tanaka, J, Kothari, M, Castrillon, E, Iida, T & Svensson, P 2021, 'Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles', The Journal of Clinical Sleep Medicine, bind 17, nr. 9, s. 1805-1813. https://doi.org/10.5664/jcsm.9284

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Vancouver

Matsuzaki S, Shimada A, Tanaka J, Kothari M, Castrillon E, Iida T o.a. Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles. The Journal of Clinical Sleep Medicine. 2021 sep;17(9):1805-1813. https://doi.org/10.5664/jcsm.9284

Author

Matsuzaki, Satoshi ; Shimada, Akiko ; Tanaka, Junko ; Kothari, Mohit ; Castrillon, Eduardo ; Iida, Takashi ; Svensson, Peter. / Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles. I: The Journal of Clinical Sleep Medicine. 2021 ; Bind 17, Nr. 9. s. 1805-1813.

Bibtex

@article{4db3a757372042ef8dcd8cc6b55cffdb,
title = "Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles",
abstract = "STUDY OBJECTIVES: This study aims to investigate if the use of a mandibular advancement device (MAD) is associated with neuroplasticity in corticomotor control of tongue and jaw muscles.METHODS: Eighteen healthy individuals participated in a randomized crossover study with 3 conditions for 2 weeks each: baseline, wearing an oral appliance (OA: sham MAD) or MAD during sleep. The custom-made MAD was constructed by positioning the mandible to 50% of its maximal protrusion limit. Transcranial magnetic stimulation (TMS) was applied to elicit motor evoked potentials (MEPs). The MEPs were assessed by constructing stimulus-response curves at four stimulus intensities: 90%, 100%, 120%, and 160% of the motor threshold (MT) from the right tongue and right masseter, and the first dorsal interosseous muscles (FDI, control) at baseline, after the first and the second intervention.RESULTS: There was a significant effect of condition and stimulus intensity both on the tongue and as well as on masseter MEPs (P < 0.01). Tongue and masseter MEPs were significantly higher at 120% and 160% following the MAD compared to the OA (P < 0.05). There were no effects of condition on FDI MEPs (P = 0.855).CONCLUSIONS: The finding suggests that MAD induces neuroplasticity in the corticomotor pathway of the tongue and jaw muscles associated with the new jaw position. Further investigations are required in patients with obstructive sleep apnea (OSA) to see if this cortical neuroplasticity may contribute or perhaps predict treatment effects with MADs in OSA.",
keywords = "Neuroplasticity, Obstructive sleep apnea, Oral appliance therapy, Transcranial magnetic stimulation",
author = "Satoshi Matsuzaki and Akiko Shimada and Junko Tanaka and Mohit Kothari and Eduardo Castrillon and Takashi Iida and Peter Svensson",
year = "2021",
month = sep,
doi = "10.5664/jcsm.9284",
language = "English",
volume = "17",
pages = "1805--1813",
journal = "The Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "9",

}

RIS

TY - JOUR

T1 - Effect of mandibular advancement device on plasticity in corticomotor control of tongue and jaw muscles

AU - Matsuzaki, Satoshi

AU - Shimada, Akiko

AU - Tanaka, Junko

AU - Kothari, Mohit

AU - Castrillon, Eduardo

AU - Iida, Takashi

AU - Svensson, Peter

PY - 2021/9

Y1 - 2021/9

N2 - STUDY OBJECTIVES: This study aims to investigate if the use of a mandibular advancement device (MAD) is associated with neuroplasticity in corticomotor control of tongue and jaw muscles.METHODS: Eighteen healthy individuals participated in a randomized crossover study with 3 conditions for 2 weeks each: baseline, wearing an oral appliance (OA: sham MAD) or MAD during sleep. The custom-made MAD was constructed by positioning the mandible to 50% of its maximal protrusion limit. Transcranial magnetic stimulation (TMS) was applied to elicit motor evoked potentials (MEPs). The MEPs were assessed by constructing stimulus-response curves at four stimulus intensities: 90%, 100%, 120%, and 160% of the motor threshold (MT) from the right tongue and right masseter, and the first dorsal interosseous muscles (FDI, control) at baseline, after the first and the second intervention.RESULTS: There was a significant effect of condition and stimulus intensity both on the tongue and as well as on masseter MEPs (P < 0.01). Tongue and masseter MEPs were significantly higher at 120% and 160% following the MAD compared to the OA (P < 0.05). There were no effects of condition on FDI MEPs (P = 0.855).CONCLUSIONS: The finding suggests that MAD induces neuroplasticity in the corticomotor pathway of the tongue and jaw muscles associated with the new jaw position. Further investigations are required in patients with obstructive sleep apnea (OSA) to see if this cortical neuroplasticity may contribute or perhaps predict treatment effects with MADs in OSA.

AB - STUDY OBJECTIVES: This study aims to investigate if the use of a mandibular advancement device (MAD) is associated with neuroplasticity in corticomotor control of tongue and jaw muscles.METHODS: Eighteen healthy individuals participated in a randomized crossover study with 3 conditions for 2 weeks each: baseline, wearing an oral appliance (OA: sham MAD) or MAD during sleep. The custom-made MAD was constructed by positioning the mandible to 50% of its maximal protrusion limit. Transcranial magnetic stimulation (TMS) was applied to elicit motor evoked potentials (MEPs). The MEPs were assessed by constructing stimulus-response curves at four stimulus intensities: 90%, 100%, 120%, and 160% of the motor threshold (MT) from the right tongue and right masseter, and the first dorsal interosseous muscles (FDI, control) at baseline, after the first and the second intervention.RESULTS: There was a significant effect of condition and stimulus intensity both on the tongue and as well as on masseter MEPs (P < 0.01). Tongue and masseter MEPs were significantly higher at 120% and 160% following the MAD compared to the OA (P < 0.05). There were no effects of condition on FDI MEPs (P = 0.855).CONCLUSIONS: The finding suggests that MAD induces neuroplasticity in the corticomotor pathway of the tongue and jaw muscles associated with the new jaw position. Further investigations are required in patients with obstructive sleep apnea (OSA) to see if this cortical neuroplasticity may contribute or perhaps predict treatment effects with MADs in OSA.

KW - Neuroplasticity

KW - Obstructive sleep apnea

KW - Oral appliance therapy

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=85114420244&partnerID=8YFLogxK

U2 - 10.5664/jcsm.9284

DO - 10.5664/jcsm.9284

M3 - Journal article

C2 - 33904391

VL - 17

SP - 1805

EP - 1813

JO - The Journal of Clinical Sleep Medicine

JF - The Journal of Clinical Sleep Medicine

SN - 1550-9389

IS - 9

ER -