Early adversity and risk for moderate to severe unipolar depressive disorder in adolescence and adulthood: A register-based study of 978,647 individuals

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Early adversity and risk for moderate to severe unipolar depressive disorder in adolescence and adulthood : A register-based study of 978,647 individuals. / Dahl, Signe Kirk; Larsen, Janne Tidselbak; Petersen, Liselotte; Ubbesen, Mads Bonde; Mortensen, Preben Bo; Munk-Olsen, Trine; Musliner, Katherine Louise.

I: Journal of Affective Disorders, Bind 214, 07.03.2017, s. 122-129.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{12f6df8a0026401aa2b92fe76e73d924,
title = "Early adversity and risk for moderate to severe unipolar depressive disorder in adolescence and adulthood: A register-based study of 978,647 individuals",
abstract = "BACKGROUND: Early adversity is a known risk factor for unipolar depression. We examined the impact of 9 types of early adversity on risk for moderate to severe unipolar depression in adolescence or adulthood, and evaluated whether these effects were moderated by gender and adversity timing.METHODS: We conducted a prospective, population-based cohort study using Danish national registers. The sample included all individuals born in Denmark between 1980 and 1998 (N=978,647). Exposure to early adversity was assessed from ages 0-15. Types of adversity included parental illness, incarceration, death, disability, and psychiatric diagnosis; family disruption; out-of-home care; and childhood abuse. Individuals were followed from age 15 until first in- or outpatient depression diagnosis (ICD-10 codes F32, F33) in a psychiatric hospital, death, emigration, or December 31st, 2013, whichever came first. Hazard ratios (HRs) were calculated using Cox regressions.RESULTS: All adversities were significantly associated with increased risk for moderate to severe adolescent/adult depression (HR range: 1.30-2.72), although the effects were attenuated after mutual adjustment (adjusted HR range: 1.06-1.70). None of the effects were moderated by gender. The effect of family disruption was strongest between ages 0-4 (HR=1.66, 95{\%} CI=1.61-1.71), while the effect of out-of-home care was strongest between ages 10-14 (HR=2.45, 95{\%} CI=2.28-2.64).LIMITATIONS: Untreated and primary-care treated depression were not measured.CONCLUSIONS: Our results support past findings that multiple types of early adversity increase risk for moderate to severe unipolar depression in adolescence and adulthood. Certain adversities may be more harmful if they occur during specific developmental time periods.",
keywords = "Journal Article",
author = "Dahl, {Signe Kirk} and Larsen, {Janne Tidselbak} and Liselotte Petersen and Ubbesen, {Mads Bonde} and Mortensen, {Preben Bo} and Trine Munk-Olsen and Musliner, {Katherine Louise}",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "3",
day = "7",
doi = "10.1016/j.jad.2017.03.014",
language = "English",
volume = "214",
pages = "122--129",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Early adversity and risk for moderate to severe unipolar depressive disorder in adolescence and adulthood

T2 - A register-based study of 978,647 individuals

AU - Dahl, Signe Kirk

AU - Larsen, Janne Tidselbak

AU - Petersen, Liselotte

AU - Ubbesen, Mads Bonde

AU - Mortensen, Preben Bo

AU - Munk-Olsen, Trine

AU - Musliner, Katherine Louise

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/3/7

Y1 - 2017/3/7

N2 - BACKGROUND: Early adversity is a known risk factor for unipolar depression. We examined the impact of 9 types of early adversity on risk for moderate to severe unipolar depression in adolescence or adulthood, and evaluated whether these effects were moderated by gender and adversity timing.METHODS: We conducted a prospective, population-based cohort study using Danish national registers. The sample included all individuals born in Denmark between 1980 and 1998 (N=978,647). Exposure to early adversity was assessed from ages 0-15. Types of adversity included parental illness, incarceration, death, disability, and psychiatric diagnosis; family disruption; out-of-home care; and childhood abuse. Individuals were followed from age 15 until first in- or outpatient depression diagnosis (ICD-10 codes F32, F33) in a psychiatric hospital, death, emigration, or December 31st, 2013, whichever came first. Hazard ratios (HRs) were calculated using Cox regressions.RESULTS: All adversities were significantly associated with increased risk for moderate to severe adolescent/adult depression (HR range: 1.30-2.72), although the effects were attenuated after mutual adjustment (adjusted HR range: 1.06-1.70). None of the effects were moderated by gender. The effect of family disruption was strongest between ages 0-4 (HR=1.66, 95% CI=1.61-1.71), while the effect of out-of-home care was strongest between ages 10-14 (HR=2.45, 95% CI=2.28-2.64).LIMITATIONS: Untreated and primary-care treated depression were not measured.CONCLUSIONS: Our results support past findings that multiple types of early adversity increase risk for moderate to severe unipolar depression in adolescence and adulthood. Certain adversities may be more harmful if they occur during specific developmental time periods.

AB - BACKGROUND: Early adversity is a known risk factor for unipolar depression. We examined the impact of 9 types of early adversity on risk for moderate to severe unipolar depression in adolescence or adulthood, and evaluated whether these effects were moderated by gender and adversity timing.METHODS: We conducted a prospective, population-based cohort study using Danish national registers. The sample included all individuals born in Denmark between 1980 and 1998 (N=978,647). Exposure to early adversity was assessed from ages 0-15. Types of adversity included parental illness, incarceration, death, disability, and psychiatric diagnosis; family disruption; out-of-home care; and childhood abuse. Individuals were followed from age 15 until first in- or outpatient depression diagnosis (ICD-10 codes F32, F33) in a psychiatric hospital, death, emigration, or December 31st, 2013, whichever came first. Hazard ratios (HRs) were calculated using Cox regressions.RESULTS: All adversities were significantly associated with increased risk for moderate to severe adolescent/adult depression (HR range: 1.30-2.72), although the effects were attenuated after mutual adjustment (adjusted HR range: 1.06-1.70). None of the effects were moderated by gender. The effect of family disruption was strongest between ages 0-4 (HR=1.66, 95% CI=1.61-1.71), while the effect of out-of-home care was strongest between ages 10-14 (HR=2.45, 95% CI=2.28-2.64).LIMITATIONS: Untreated and primary-care treated depression were not measured.CONCLUSIONS: Our results support past findings that multiple types of early adversity increase risk for moderate to severe unipolar depression in adolescence and adulthood. Certain adversities may be more harmful if they occur during specific developmental time periods.

KW - Journal Article

U2 - 10.1016/j.jad.2017.03.014

DO - 10.1016/j.jad.2017.03.014

M3 - Journal article

C2 - 28288406

VL - 214

SP - 122

EP - 129

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -