Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

TY - JOUR

T1 - Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

AU - Nielsen, Marie Bodilsen

AU - Ravlo, Kristian

AU - Eijken, Marco

AU - Krogstrup, Nicoline V

AU - Svendsen, Morten Bue

AU - Abdel-Halim, Chadi

AU - Petersen, Mikkel Steen

AU - Birn, Henrik

AU - Oltean, Mihai

AU - Jespersen, Bente

AU - Møller, Bjarne K

N1 - Publisher Copyright: © 2021 British Society for Immunology. © 2021 British Society for Immunology.

PY - 2021/11

Y1 - 2021/11

N2 - Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

AB - Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

KW - cytokines

KW - dendritic cells

KW - immunology

KW - kidney transplantation

KW - remote ischaemic conditioning

U2 - 10.1111/cei.13658

DO - 10.1111/cei.13658

M3 - Journal article

C2 - 34473350

SN - 0964-2536

VL - 206

SP - 226

EP - 236

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -