Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial

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Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial. / Kelbaek, Henning; Thuesen, Leif; Helqvist, Steffen; Clemmensen, Peter; Kløvgaard, Lene; Kaltoft, Anne; Andersen, Bente; Thuesen, Helle Holm Højdahl; Engstrøm, Thomas; Bøtker, Hans E; Saunamäki, Kari; Krusell, Lars R; Jørgensen, Erik; Hansen, Hans-Henrik T; Christiansen, Evald H; Ravkilde, Jan; Køber, Lars; Kofoed, Klaus F; Terkelsen, Christian J; Lassen, Jens F; DEDICATION Investigators.

I: Circulation, Bind 118, Nr. 11, 2008, s. 1155-62.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kelbaek, H, Thuesen, L, Helqvist, S, Clemmensen, P, Kløvgaard, L, Kaltoft, A, Andersen, B, Thuesen, HHH, Engstrøm, T, Bøtker, HE, Saunamäki, K, Krusell, LR, Jørgensen, E, Hansen, H-HT, Christiansen, EH, Ravkilde, J, Køber, L, Kofoed, KF, Terkelsen, CJ, Lassen, JF & DEDICATION Investigators 2008, 'Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial', Circulation, bind 118, nr. 11, s. 1155-62. https://doi.org/10.1161/CIRCULATIONAHA.107.758698

APA

CBE

Kelbaek H, Thuesen L, Helqvist S, Clemmensen P, Kløvgaard L, Kaltoft A, Andersen B, Thuesen HHH, Engstrøm T, Bøtker HE, Saunamäki K, Krusell LR, Jørgensen E, Hansen H-HT, Christiansen EH, Ravkilde J, Køber L, Kofoed KF, Terkelsen CJ, Lassen JF, DEDICATION Investigators. 2008. Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial. Circulation. 118(11):1155-62. https://doi.org/10.1161/CIRCULATIONAHA.107.758698

MLA

Vancouver

Author

Kelbaek, Henning ; Thuesen, Leif ; Helqvist, Steffen ; Clemmensen, Peter ; Kløvgaard, Lene ; Kaltoft, Anne ; Andersen, Bente ; Thuesen, Helle Holm Højdahl ; Engstrøm, Thomas ; Bøtker, Hans E ; Saunamäki, Kari ; Krusell, Lars R ; Jørgensen, Erik ; Hansen, Hans-Henrik T ; Christiansen, Evald H ; Ravkilde, Jan ; Køber, Lars ; Kofoed, Klaus F ; Terkelsen, Christian J ; Lassen, Jens F ; DEDICATION Investigators. / Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial. I: Circulation. 2008 ; Bind 118, Nr. 11. s. 1155-62.

Bibtex

@article{94635df0e17b11dd8fc3000ea68e967b,
title = "Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial",
abstract = "BACKGROUND: Implantation of drug-eluting stents (DES) limits the rate of coronary restenosis in most patients with coronary artery disease, but data are scarce with regard to their use in patients with ST-segment-elevation myocardial infarction and in connection with distal protection of the microvascular perfusion during primary percutaneous coronary intervention. METHODS AND RESULTS: We randomly assigned 626 patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction to have a DES or a bare metal stent implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Quantitative coronary angiography was performed during the index treatment and 8 months later. The primary end point was loss of the lumen diameter in the infarct-related lesion induced by neointimal proliferation. Patients were comparable with regard to baseline demographic and angiographic characteristics. The mean late lumen loss was significantly lower in patients treated with a DES (0.06 mm; SD, 0.66 mm) than in patients who had a bare metal stent implanted (0.47 mm; SD, 0.69 mm; P<0.001). The rate of the composite end point of cardiac death, recurrent myocardial infarction, and target lesion revascularization was 8.6{\%} in the DES group versus 14.4{\%} in the bare metal stent group (P=0.03). Cardiac death occurred in 4.2{\%} and 1.6{\%} of the patients (P=0.09) and stent thrombosis occurred in 2.0{\%} and 2.6{\%} (P=0.72), respectively. CONCLUSIONS: Implantation of DES improves the angiographic outcome and need for repeat revascularization without increasing the short-term risk of stent thrombosis but has a tendency to increase cardiac death in patients with ST-segment-elevation myocardial infarction.",
keywords = "Angioplasty, Transluminal, Percutaneous Coronary, Cell Proliferation, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Death, Drug-Eluting Stents, Follow-Up Studies, Humans, Myocardial Infarction, Stents, Thrombosis, Treatment Outcome, Tunica Intima",
author = "Henning Kelbaek and Leif Thuesen and Steffen Helqvist and Peter Clemmensen and Lene Kl{\o}vgaard and Anne Kaltoft and Bente Andersen and Thuesen, {Helle Holm H{\o}jdahl} and Thomas Engstr{\o}m and B{\o}tker, {Hans E} and Kari Saunam{\"a}ki and Krusell, {Lars R} and Erik J{\o}rgensen and Hansen, {Hans-Henrik T} and Christiansen, {Evald H} and Jan Ravkilde and Lars K{\o}ber and Kofoed, {Klaus F} and Terkelsen, {Christian J} and Lassen, {Jens F} and {DEDICATION Investigators}",
year = "2008",
doi = "10.1161/CIRCULATIONAHA.107.758698",
language = "English",
volume = "118",
pages = "1155--62",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial

AU - Kelbaek, Henning

AU - Thuesen, Leif

AU - Helqvist, Steffen

AU - Clemmensen, Peter

AU - Kløvgaard, Lene

AU - Kaltoft, Anne

AU - Andersen, Bente

AU - Thuesen, Helle Holm Højdahl

AU - Engstrøm, Thomas

AU - Bøtker, Hans E

AU - Saunamäki, Kari

AU - Krusell, Lars R

AU - Jørgensen, Erik

AU - Hansen, Hans-Henrik T

AU - Christiansen, Evald H

AU - Ravkilde, Jan

AU - Køber, Lars

AU - Kofoed, Klaus F

AU - Terkelsen, Christian J

AU - Lassen, Jens F

AU - DEDICATION Investigators

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Implantation of drug-eluting stents (DES) limits the rate of coronary restenosis in most patients with coronary artery disease, but data are scarce with regard to their use in patients with ST-segment-elevation myocardial infarction and in connection with distal protection of the microvascular perfusion during primary percutaneous coronary intervention. METHODS AND RESULTS: We randomly assigned 626 patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction to have a DES or a bare metal stent implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Quantitative coronary angiography was performed during the index treatment and 8 months later. The primary end point was loss of the lumen diameter in the infarct-related lesion induced by neointimal proliferation. Patients were comparable with regard to baseline demographic and angiographic characteristics. The mean late lumen loss was significantly lower in patients treated with a DES (0.06 mm; SD, 0.66 mm) than in patients who had a bare metal stent implanted (0.47 mm; SD, 0.69 mm; P<0.001). The rate of the composite end point of cardiac death, recurrent myocardial infarction, and target lesion revascularization was 8.6% in the DES group versus 14.4% in the bare metal stent group (P=0.03). Cardiac death occurred in 4.2% and 1.6% of the patients (P=0.09) and stent thrombosis occurred in 2.0% and 2.6% (P=0.72), respectively. CONCLUSIONS: Implantation of DES improves the angiographic outcome and need for repeat revascularization without increasing the short-term risk of stent thrombosis but has a tendency to increase cardiac death in patients with ST-segment-elevation myocardial infarction.

AB - BACKGROUND: Implantation of drug-eluting stents (DES) limits the rate of coronary restenosis in most patients with coronary artery disease, but data are scarce with regard to their use in patients with ST-segment-elevation myocardial infarction and in connection with distal protection of the microvascular perfusion during primary percutaneous coronary intervention. METHODS AND RESULTS: We randomly assigned 626 patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction to have a DES or a bare metal stent implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Quantitative coronary angiography was performed during the index treatment and 8 months later. The primary end point was loss of the lumen diameter in the infarct-related lesion induced by neointimal proliferation. Patients were comparable with regard to baseline demographic and angiographic characteristics. The mean late lumen loss was significantly lower in patients treated with a DES (0.06 mm; SD, 0.66 mm) than in patients who had a bare metal stent implanted (0.47 mm; SD, 0.69 mm; P<0.001). The rate of the composite end point of cardiac death, recurrent myocardial infarction, and target lesion revascularization was 8.6% in the DES group versus 14.4% in the bare metal stent group (P=0.03). Cardiac death occurred in 4.2% and 1.6% of the patients (P=0.09) and stent thrombosis occurred in 2.0% and 2.6% (P=0.72), respectively. CONCLUSIONS: Implantation of DES improves the angiographic outcome and need for repeat revascularization without increasing the short-term risk of stent thrombosis but has a tendency to increase cardiac death in patients with ST-segment-elevation myocardial infarction.

KW - Angioplasty, Transluminal, Percutaneous Coronary

KW - Cell Proliferation

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Coronary Stenosis

KW - Death

KW - Drug-Eluting Stents

KW - Follow-Up Studies

KW - Humans

KW - Myocardial Infarction

KW - Stents

KW - Thrombosis

KW - Treatment Outcome

KW - Tunica Intima

U2 - 10.1161/CIRCULATIONAHA.107.758698

DO - 10.1161/CIRCULATIONAHA.107.758698

M3 - Journal article

C2 - 18725489

VL - 118

SP - 1155

EP - 1162

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 11

ER -