Department of Clinical Medicine

TY - JOUR

T1 - Drinking water arsenic and adverse reproductive outcomes in men and women

T2 - A systematic PRISMA review

AU - Barsøe, Ida M.

AU - Ebdrup, Ninna H.

AU - Clausen, Hannah S.

AU - Lyngsø, Julie

AU - Schullehner, Jörg

AU - Ramlau‐Hansen, Cecilia H.

AU - Bay, Bjørn

AU - Knudsen, Ulla B.

N1 - Publisher Copyright: © 2021 by the authors.

PY - 2021/7

Y1 - 2021/7

N2 - Infertility is a worldwide health issue, but mechanisms of both male and female reproductive toxicity remain to be elucidated. So far, a limited focus has been on potentially harmful environmental factors such as arsenic, which is naturally occurring in groundwater. The objective of this review was to systematically investigate the association between arsenic in drinking water and adverse reproductive outcomes in men and women of fertile age. We conducted a systematic literature search and included case‐control studies and cohort studies reporting on decreased semen quality characteristics, increased time to pregnancy, infertility, or spontaneous abortion. In total, 433 articles were screened and ultimately, eight studies were included. Included literature was quality assessed with the Newcastle‐Ottawa Scale. Findings were reported in a narrative synthesis. Only one study investigated male fertility. An association between increasing arsenic exposure and decreasing semen quality characteristics was found, as well as an indication of arsenic accumulation in seminal plasma. These findings are, however, at high arsenic levels (>1000 μg/L). No consistent evidence was found to support the hypothesis that arsenic exposure from drinking water is a cause of longer waiting time to pregnancy or spontaneous abortion, being the only endpoints investigated in the included literature. In conclusion; the evidence is sparse and of varying quality, however, it does warrant attention, as it conflicts with existing evidence, mainly from cross‐sectional or ecologic studies.

AB - Infertility is a worldwide health issue, but mechanisms of both male and female reproductive toxicity remain to be elucidated. So far, a limited focus has been on potentially harmful environmental factors such as arsenic, which is naturally occurring in groundwater. The objective of this review was to systematically investigate the association between arsenic in drinking water and adverse reproductive outcomes in men and women of fertile age. We conducted a systematic literature search and included case‐control studies and cohort studies reporting on decreased semen quality characteristics, increased time to pregnancy, infertility, or spontaneous abortion. In total, 433 articles were screened and ultimately, eight studies were included. Included literature was quality assessed with the Newcastle‐Ottawa Scale. Findings were reported in a narrative synthesis. Only one study investigated male fertility. An association between increasing arsenic exposure and decreasing semen quality characteristics was found, as well as an indication of arsenic accumulation in seminal plasma. These findings are, however, at high arsenic levels (>1000 μg/L). No consistent evidence was found to support the hypothesis that arsenic exposure from drinking water is a cause of longer waiting time to pregnancy or spontaneous abortion, being the only endpoints investigated in the included literature. In conclusion; the evidence is sparse and of varying quality, however, it does warrant attention, as it conflicts with existing evidence, mainly from cross‐sectional or ecologic studies.

KW - Arsenic

KW - Drinking water

KW - Infertility

KW - Reproductive outcome

KW - Semen quality

KW - Spontaneous abortion

UR - http://www.scopus.com/inward/record.url?scp=85111129818&partnerID=8YFLogxK

U2 - 10.3390/w13141885

DO - 10.3390/w13141885

M3 - Review

AN - SCOPUS:85111129818

VL - 13

JO - Water

JF - Water

SN - 2073-4441

IS - 14

M1 - 1885

ER -