Does the route matter? A preclinical review of mesenchymal stromal cell delivery to the kidney

TY - JOUR

T1 - Does the route matter?

T2 - A preclinical review of mesenchymal stromal cell delivery to the kidney

AU - Kresse, Jean-Claude

AU - Gregersen, Emil

AU - Atay, Jasmine Cicek Leifing

AU - Eijken, Marco

AU - Nørregaard, Rikke

PY - 2023/12

Y1 - 2023/12

N2 - Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical animal models and holds great promise for the treatment of kidney diseases. It is becoming increasingly evident that the efficacy of MSC therapy is dependent on several factors including dosage, the tissue source of MSCs, the route of delivery and timing of administration. In a time where MSC therapy is moving from preclinical research to clinically therapeutic use, the importance of choice of delivery method, modality, and administration route increases. In this review, we provide an overview of the different MSC delivery routes used in preclinical kidney disease models, highlight the recent advances in the field, and summarize studies comparing delivery routes of MSCs to the kidney.

AB - Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical animal models and holds great promise for the treatment of kidney diseases. It is becoming increasingly evident that the efficacy of MSC therapy is dependent on several factors including dosage, the tissue source of MSCs, the route of delivery and timing of administration. In a time where MSC therapy is moving from preclinical research to clinically therapeutic use, the importance of choice of delivery method, modality, and administration route increases. In this review, we provide an overview of the different MSC delivery routes used in preclinical kidney disease models, highlight the recent advances in the field, and summarize studies comparing delivery routes of MSCs to the kidney.

KW - Kidney disease

KW - local delivery

KW - mesenchymal stem cells

KW - mesenchymal stromal cells

KW - systemic delivery

UR - http://www.scopus.com/inward/record.url?scp=85172144751&partnerID=8YFLogxK

U2 - 10.1111/apm.13352

DO - 10.1111/apm.13352

M3 - Review

C2 - 37750005

SN - 0903-4641

VL - 131

SP - 687

EP - 697

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

IS - 12

ER -