DNA origami design of dolphin-shaped structures with flexible tails

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DNA origami design of dolphin-shaped structures with flexible tails. / Andersen, Ebbe S; Dong, Mingdong; Nielsen, Morten M; Jahn, Kasper; Lind-Thomsen, Allan; Mamdouh, Wael; Gothelf, Kurt V; Besenbacher, Flemming; Kjems, Jørgen.

I: A C S Nano, Bind 2, Nr. 6, 2008, s. 1213-8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Lind-Thomsen, A., Mamdouh, W., ... Kjems, J. (2008). DNA origami design of dolphin-shaped structures with flexible tails. A C S Nano, 2(6), 1213-8. https://doi.org/10.1021/nn800215j

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MLA

Vancouver

Andersen ES, Dong M, Nielsen MM, Jahn K, Lind-Thomsen A, Mamdouh W o.a. DNA origami design of dolphin-shaped structures with flexible tails. A C S Nano. 2008;2(6):1213-8. https://doi.org/10.1021/nn800215j

Author

Andersen, Ebbe S ; Dong, Mingdong ; Nielsen, Morten M ; Jahn, Kasper ; Lind-Thomsen, Allan ; Mamdouh, Wael ; Gothelf, Kurt V ; Besenbacher, Flemming ; Kjems, Jørgen. / DNA origami design of dolphin-shaped structures with flexible tails. I: A C S Nano. 2008 ; Bind 2, Nr. 6. s. 1213-8.

Bibtex

@article{01605ff0726911df8c1a000ea68e967b,
title = "DNA origami design of dolphin-shaped structures with flexible tails",
abstract = "The DNA origami method allows the folding of long, single-stranded DNA sequences into arbitrary two-dimensional structures by a set of designed oligonucleotides. The method has revealed an unexpected strength and efficiency for programmed self-assembly of molecular nanostructures and makes it possible to produce fully addressable nanostructures with wide-reaching application potential within the emerging area of nanoscience. Here we present a user-friendly software package for designing DNA origami structures ( http://www.cdna.dk/origami ) and demonstrate its use by the design of a dolphin-like DNA origami structure that was imaged by high-resolution AFM in liquid. The software package provides automatic generation of DNA origami structures, manual editing, interactive overviews, atomic models, tracks the design history, and has a fully extendable toolbox. From the AFM images, it was demonstrated that different designs of the dolphin tail region provided various levels of flexibility in a predictable fashion. Finally, we show that the addition of specific attachment sites promotes dimerization between two independently self-assembled dolphin structures, and that these interactions stabilize the flexible tail.",
keywords = "Computer Simulation, Computer-Aided Design, DNA, Macromolecular Substances, Models, Chemical, Models, Molecular, Molecular Conformation, Nanostructures, Nanotechnology, Particle Size, Software, Surface Properties",
author = "Andersen, {Ebbe S} and Mingdong Dong and Nielsen, {Morten M} and Kasper Jahn and Allan Lind-Thomsen and Wael Mamdouh and Gothelf, {Kurt V} and Flemming Besenbacher and J{\o}rgen Kjems",
year = "2008",
doi = "10.1021/nn800215j",
language = "English",
volume = "2",
pages = "1213--8",
journal = "A C S Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "6",

}

RIS

TY - JOUR

T1 - DNA origami design of dolphin-shaped structures with flexible tails

AU - Andersen, Ebbe S

AU - Dong, Mingdong

AU - Nielsen, Morten M

AU - Jahn, Kasper

AU - Lind-Thomsen, Allan

AU - Mamdouh, Wael

AU - Gothelf, Kurt V

AU - Besenbacher, Flemming

AU - Kjems, Jørgen

PY - 2008

Y1 - 2008

N2 - The DNA origami method allows the folding of long, single-stranded DNA sequences into arbitrary two-dimensional structures by a set of designed oligonucleotides. The method has revealed an unexpected strength and efficiency for programmed self-assembly of molecular nanostructures and makes it possible to produce fully addressable nanostructures with wide-reaching application potential within the emerging area of nanoscience. Here we present a user-friendly software package for designing DNA origami structures ( http://www.cdna.dk/origami ) and demonstrate its use by the design of a dolphin-like DNA origami structure that was imaged by high-resolution AFM in liquid. The software package provides automatic generation of DNA origami structures, manual editing, interactive overviews, atomic models, tracks the design history, and has a fully extendable toolbox. From the AFM images, it was demonstrated that different designs of the dolphin tail region provided various levels of flexibility in a predictable fashion. Finally, we show that the addition of specific attachment sites promotes dimerization between two independently self-assembled dolphin structures, and that these interactions stabilize the flexible tail.

AB - The DNA origami method allows the folding of long, single-stranded DNA sequences into arbitrary two-dimensional structures by a set of designed oligonucleotides. The method has revealed an unexpected strength and efficiency for programmed self-assembly of molecular nanostructures and makes it possible to produce fully addressable nanostructures with wide-reaching application potential within the emerging area of nanoscience. Here we present a user-friendly software package for designing DNA origami structures ( http://www.cdna.dk/origami ) and demonstrate its use by the design of a dolphin-like DNA origami structure that was imaged by high-resolution AFM in liquid. The software package provides automatic generation of DNA origami structures, manual editing, interactive overviews, atomic models, tracks the design history, and has a fully extendable toolbox. From the AFM images, it was demonstrated that different designs of the dolphin tail region provided various levels of flexibility in a predictable fashion. Finally, we show that the addition of specific attachment sites promotes dimerization between two independently self-assembled dolphin structures, and that these interactions stabilize the flexible tail.

KW - Computer Simulation

KW - Computer-Aided Design

KW - DNA

KW - Macromolecular Substances

KW - Models, Chemical

KW - Models, Molecular

KW - Molecular Conformation

KW - Nanostructures

KW - Nanotechnology

KW - Particle Size

KW - Software

KW - Surface Properties

U2 - 10.1021/nn800215j

DO - 10.1021/nn800215j

M3 - Journal article

VL - 2

SP - 1213

EP - 1218

JO - A C S Nano

JF - A C S Nano

SN - 1936-0851

IS - 6

ER -