Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Line Dam Heftdal
  • ,
  • Anne Gitte Loft
  • Oliver Hendricks, d Institute of Regional Health Research , University of Southern Denmark , Odense , Denmark.
  • ,
  • Alice Ashouri Christiansen, c King Christian 10th Hospital for Rheumatic Diseases, Gråsten and Hospital of Southern Jutland , Jutland , Denmark.
  • ,
  • Berit Schiøttz-Christensen, d Institute of Regional Health Research , University of Southern Denmark , Odense , Denmark., e Spine Centre of Southern Denmark, Hospital Lillebaelt Middelfart , Middelfart , Denmark.
  • ,
  • Bodil Arnbak, g Department of Radiology , Hospital Lillebaelt , Vejle , Denmark.
  • ,
  • Anne Grethe Jurik
  • René Østgård
  • Bent Winding Deleuran
  • Holger Jon Møller
  • Stinne Ravn Greisen

The chronic joint inflammation in axial spondyloarthritis (axSpA) is characterized by infiltration of activated macrophages. The haptoglobin-hemoglobin receptor CD163 and the mannose receptor CD206 are strongly expressed on M2c and M2a macrophages, respectively. We measured the soluble forms of the receptors (sCD163 and sCD206) in plasma (PL) in two axSpA cohorts. All patients fulfil the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axSpA and/or the 1984 modified New York criteria for ankylosing spondylitis. The first cohort included anti-TNF-α treated patients with active axSpA (n = 30); the second cohort included patients in early disease stages (n = 38). Plasma sCD163 and sCD206 were both within the reference interval of healthy controls (HC), but sCD163 decreased slightly during anti-TNF-α treatment [baseline: 1.49 mg/L (IQR: 1.22-1.77 mg/L, 12 weeks: 1.29 (IQR: 1.09-1.57) mg/L, 20 weeks: 1.25 (IQR: 0.99-1.75) mg/L, 52 weeks: 1.39 (IQR: 1.15-1.78) mg/L], while sCD206 increased [baseline: 0.17 (IQR: 0.13-0.21) mg/L, 12 weeks: 0.19 (0.16-0.23) mg/L, 20 weeks: 0.20 (0.14-0.24) mg/L, 52: 0.19 (IQR: 0.14-0.23) mg/L], pointing toward a shift in polarization of involved macrophages. Plasma levels of sCD206 proved significantly higher in patients with early disease stages and definite radiological sacroiliitis (n = 10). This was not the case for sCD163. A significant increase in response to anti-TNF-α treatment, could suggest sCD206 as a marker of response to anti-TNF-α treatment, however, the potential for the two macrophage markers as diagnostic and prognostic indicators of disease in axSpA is weak.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clnical and Laboratory Investigation
Vol/bind78
Nummer6
Sider (fra-til)483-489
Antal sider7
ISSN0036-5513
DOI
StatusUdgivet - okt. 2018

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