TY - JOUR
T1 - Distant metastases in squamous cell carcinoma of the pharynx and larynx
T2 - a population-based DAHANCA study
AU - Kjems, Julie
AU - Zukauskaite, Ruta
AU - Johansen, Jørgen
AU - Eriksen, Jesper Grau
AU - Lassen, Pernille
AU - Andersen, Elo
AU - Andersen, Maria
AU - Farhadi, Mohammad
AU - Overgaard, Jens
AU - Vogelius, Ivan R.
AU - Friborg, Jeppe
N1 - Publisher Copyright:
© 2021 Acta Oncologica Foundation.
PY - 2021
Y1 - 2021
N2 - Background: In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding outcomes are scarce. Therefore, we investigated the incidence, location of metastases and overall survival of patients with M1 and DM. Materials and methods: Patients diagnosed with squamous cell carcinoma of the pharynx and larynx in Denmark 2008–2017 were identified in the Danish Head and Neck Cancer Group (DAHANCA) database. We identified 7300 patients, of whom 197 (3%) had M1 and 498 (8%) developed DM during follow-up. Results: The 5-year cumulative incidence of DM was 8%. 1- and 2-year overall survival for DM (27% and 13%) vs. M1 (28% and 9%) were equally poor. There was no significant difference in location of metastases for M1 and DM and the most frequently involved organs were lungs, bone, lymph nodes and liver, in descending order. In oropharyngeal squamous cell carcinomas, the location of metastases did not differ by p16-status. For p16-positive patients, 21% of DM occurred later than three years of follow-up compared to 7% of p16-negative patients. Conclusion: Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.
AB - Background: In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding outcomes are scarce. Therefore, we investigated the incidence, location of metastases and overall survival of patients with M1 and DM. Materials and methods: Patients diagnosed with squamous cell carcinoma of the pharynx and larynx in Denmark 2008–2017 were identified in the Danish Head and Neck Cancer Group (DAHANCA) database. We identified 7300 patients, of whom 197 (3%) had M1 and 498 (8%) developed DM during follow-up. Results: The 5-year cumulative incidence of DM was 8%. 1- and 2-year overall survival for DM (27% and 13%) vs. M1 (28% and 9%) were equally poor. There was no significant difference in location of metastases for M1 and DM and the most frequently involved organs were lungs, bone, lymph nodes and liver, in descending order. In oropharyngeal squamous cell carcinomas, the location of metastases did not differ by p16-status. For p16-positive patients, 21% of DM occurred later than three years of follow-up compared to 7% of p16-negative patients. Conclusion: Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.
KW - Distant metastases
KW - head and neck cancer
KW - human papillomavirus
KW - radiotherapy
KW - the pattern of failure
UR - http://www.scopus.com/inward/record.url?scp=85112080620&partnerID=8YFLogxK
U2 - 10.1080/0284186X.2021.1959056
DO - 10.1080/0284186X.2021.1959056
M3 - Journal article
C2 - 34369265
AN - SCOPUS:85112080620
SN - 0284-186X
VL - 60
SP - 1472
EP - 1480
JO - Acta Oncologica
JF - Acta Oncologica
IS - 11
ER -