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Direction selectivity in retinal bipolar cell axon terminals

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Direction selectivity in retinal bipolar cell axon terminals. / Matsumoto, Akihiro; Agbariah, Weaam; Nolte, Stella Solveig et al.

I: Neuron, Bind 109, Nr. 18, 09.2021, s. 2928-2942.e8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Matsumoto, A, Agbariah, W, Nolte, SS, Andrawos, R, Levi, H, Sabbah, S & Yonehara, K 2021, 'Direction selectivity in retinal bipolar cell axon terminals', Neuron, bind 109, nr. 18, s. 2928-2942.e8. https://doi.org/10.1016/j.neuron.2021.07.008

APA

Matsumoto, A., Agbariah, W., Nolte, S. S., Andrawos, R., Levi, H., Sabbah, S., & Yonehara, K. (2021). Direction selectivity in retinal bipolar cell axon terminals. Neuron, 109(18), 2928-2942.e8. https://doi.org/10.1016/j.neuron.2021.07.008

CBE

Matsumoto A, Agbariah W, Nolte SS, Andrawos R, Levi H, Sabbah S, Yonehara K. 2021. Direction selectivity in retinal bipolar cell axon terminals. Neuron. 109(18):2928-2942.e8. https://doi.org/10.1016/j.neuron.2021.07.008

MLA

Matsumoto, Akihiro et al. "Direction selectivity in retinal bipolar cell axon terminals". Neuron. 2021, 109(18). 2928-2942.e8. https://doi.org/10.1016/j.neuron.2021.07.008

Vancouver

Matsumoto A, Agbariah W, Nolte SS, Andrawos R, Levi H, Sabbah S et al. Direction selectivity in retinal bipolar cell axon terminals. Neuron. 2021 sep.;109(18):2928-2942.e8. doi: 10.1016/j.neuron.2021.07.008

Author

Matsumoto, Akihiro ; Agbariah, Weaam ; Nolte, Stella Solveig et al. / Direction selectivity in retinal bipolar cell axon terminals. I: Neuron. 2021 ; Bind 109, Nr. 18. s. 2928-2942.e8.

Bibtex

@article{3208f90cf32548ada44e2b5ec4ef97df,
title = "Direction selectivity in retinal bipolar cell axon terminals",
abstract = "The ability to encode the direction of image motion is fundamental to our sense of vision. Direction selectivity along the four cardinal directions is thought to originate in direction-selective ganglion cells (DSGCs) because of directionally tuned GABAergic suppression by starburst cells. Here, by utilizing two-photon glutamate imaging to measure synaptic release, we reveal that direction selectivity along all four directions arises earlier than expected at bipolar cell outputs. Individual bipolar cells contained four distinct populations of axon terminal boutons with different preferred directions. We further show that this bouton-specific tuning relies on cholinergic excitation from starburst cells and GABAergic inhibition from wide-field amacrine cells. DSGCs received both tuned directionally aligned inputs and untuned inputs from among heterogeneously tuned glutamatergic bouton populations. Thus, directional tuning in the excitatory visual pathway is incrementally refined at the bipolar cell axon terminals and their recipient DSGC dendrites by two different neurotransmitters co-released from starburst cells.",
keywords = "bipolar cells, cholinergic transmission, direction selectivity, glutamatergic transmission, motion processing, retina, starburst amacrine cells",
author = "Akihiro Matsumoto and Weaam Agbariah and Nolte, {Stella Solveig} and Rawan Andrawos and Hadara Levi and Shai Sabbah and Keisuke Yonehara",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = sep,
doi = "10.1016/j.neuron.2021.07.008",
language = "English",
volume = "109",
pages = "2928--2942.e8",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "18",

}

RIS

TY - JOUR

T1 - Direction selectivity in retinal bipolar cell axon terminals

AU - Matsumoto, Akihiro

AU - Agbariah, Weaam

AU - Nolte, Stella Solveig

AU - Andrawos, Rawan

AU - Levi, Hadara

AU - Sabbah, Shai

AU - Yonehara, Keisuke

N1 - Publisher Copyright: © 2021 The Author(s)

PY - 2021/9

Y1 - 2021/9

N2 - The ability to encode the direction of image motion is fundamental to our sense of vision. Direction selectivity along the four cardinal directions is thought to originate in direction-selective ganglion cells (DSGCs) because of directionally tuned GABAergic suppression by starburst cells. Here, by utilizing two-photon glutamate imaging to measure synaptic release, we reveal that direction selectivity along all four directions arises earlier than expected at bipolar cell outputs. Individual bipolar cells contained four distinct populations of axon terminal boutons with different preferred directions. We further show that this bouton-specific tuning relies on cholinergic excitation from starburst cells and GABAergic inhibition from wide-field amacrine cells. DSGCs received both tuned directionally aligned inputs and untuned inputs from among heterogeneously tuned glutamatergic bouton populations. Thus, directional tuning in the excitatory visual pathway is incrementally refined at the bipolar cell axon terminals and their recipient DSGC dendrites by two different neurotransmitters co-released from starburst cells.

AB - The ability to encode the direction of image motion is fundamental to our sense of vision. Direction selectivity along the four cardinal directions is thought to originate in direction-selective ganglion cells (DSGCs) because of directionally tuned GABAergic suppression by starburst cells. Here, by utilizing two-photon glutamate imaging to measure synaptic release, we reveal that direction selectivity along all four directions arises earlier than expected at bipolar cell outputs. Individual bipolar cells contained four distinct populations of axon terminal boutons with different preferred directions. We further show that this bouton-specific tuning relies on cholinergic excitation from starburst cells and GABAergic inhibition from wide-field amacrine cells. DSGCs received both tuned directionally aligned inputs and untuned inputs from among heterogeneously tuned glutamatergic bouton populations. Thus, directional tuning in the excitatory visual pathway is incrementally refined at the bipolar cell axon terminals and their recipient DSGC dendrites by two different neurotransmitters co-released from starburst cells.

KW - bipolar cells

KW - cholinergic transmission

KW - direction selectivity

KW - glutamatergic transmission

KW - motion processing

KW - retina

KW - starburst amacrine cells

UR - http://www.scopus.com/inward/record.url?scp=85115008216&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2021.07.008

DO - 10.1016/j.neuron.2021.07.008

M3 - Journal article

C2 - 34390651

AN - SCOPUS:85115008216

VL - 109

SP - 2928-2942.e8

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 18

ER -