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Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

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The tyrosine kinase receptor HER4 is a member of the epidermal growth factor receptor (EGFR) family. It plays diverse roles in cancer development and cancer progression and can both exert oncogenic and tumour-suppressive activities. Alternatively spliced isoforms of HER4 are critical to the different signalling possibilities of HER4.
OriginalsprogEngelsk
TidsskriftB J C
Vol/bind108
Nummer11
Sider (fra-til)2291-2298
Antal sider8
ISSN0007-0920
DOI
StatusUdgivet - 11 jun. 2013

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