Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow

Karoline Thorum Neumann; Sebastian Klimczyk; Mia Burhardt; Benny Bang-Andersen; Troels Skrydstrup; Anders Thyboe Lindhardt

doi:10.1021/acscatal.6b01045

Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow

Karoline Thorum Neumann, Sebastian Klimczyk, Mia Burhardt, Benny Bang-Andersen, Troels Skrydstrup, Anders Thyboe Lindhardt

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of functional groups, are carried out in a two-chamber setup with ex situ generated hydrogen. The reaction setup is highly suitable for deuterium labeling. The trans-selective hydrogenation was extrapolated to a transfer hydrogenation protocol, employing a packed bed immobilized ruthenium hydride catalyst in continuous flow with a retention time of only 10 min.

Originalsprog	Engelsk
Tidsskrift	ACS Catalysis
Vol/bind	6
Nummer	7
Sider (fra-til)	4710-4714
Antal sider	5
ISSN	2155-5435
DOI	https://doi.org/10.1021/acscatal.6b01045
Status	Udgivet - 7 jun. 2016

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title = "Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow",

abstract = "An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of functional groups, are carried out in a two-chamber setup with ex situ generated hydrogen. The reaction setup is highly suitable for deuterium labeling. The trans-selective hydrogenation was extrapolated to a transfer hydrogenation protocol, employing a packed bed immobilized ruthenium hydride catalyst in continuous flow with a retention time of only 10 min.",

keywords = "alkynes, continuous flow, deuterium labeling, hydrogenation, ruthenium catalysis, trans-alkenes",

author = "Neumann, {Karoline Thorum} and Sebastian Klimczyk and Mia Burhardt and Benny Bang-Andersen and Troels Skrydstrup and Lindhardt, {Anders Thyboe}",

year = "2016",

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Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow. / Neumann, Karoline Thorum; Klimczyk, Sebastian; Burhardt, Mia et al.
I: ACS Catalysis, Bind 6, Nr. 7, 07.06.2016, s. 4710-4714.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow

AU - Neumann, Karoline Thorum

AU - Klimczyk, Sebastian

AU - Burhardt, Mia

AU - Bang-Andersen, Benny

AU - Skrydstrup, Troels

AU - Lindhardt, Anders Thyboe

PY - 2016/6/7

Y1 - 2016/6/7

N2 - An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of functional groups, are carried out in a two-chamber setup with ex situ generated hydrogen. The reaction setup is highly suitable for deuterium labeling. The trans-selective hydrogenation was extrapolated to a transfer hydrogenation protocol, employing a packed bed immobilized ruthenium hydride catalyst in continuous flow with a retention time of only 10 min.

AB - An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of functional groups, are carried out in a two-chamber setup with ex situ generated hydrogen. The reaction setup is highly suitable for deuterium labeling. The trans-selective hydrogenation was extrapolated to a transfer hydrogenation protocol, employing a packed bed immobilized ruthenium hydride catalyst in continuous flow with a retention time of only 10 min.

KW - alkynes

KW - continuous flow

KW - deuterium labeling

KW - hydrogenation

KW - ruthenium catalysis

KW - trans-alkenes

UR - http://www.scopus.com/inward/record.url?scp=84977107227&partnerID=8YFLogxK

U2 - 10.1021/acscatal.6b01045

DO - 10.1021/acscatal.6b01045

M3 - Journal article

SN - 2155-5435

VL - 6

SP - 4710

EP - 4714

JO - ACS Catalysis

JF - ACS Catalysis

IS - 7

ER -

Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow

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