Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

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An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.

OriginalsprogEngelsk
TidsskriftAngewandte Chemie - International Edition
Vol/bind59
Nummer21
Sider (fra-til)8099-8103
Antal sider5
ISSN1433-7851
DOI
StatusUdgivet - maj 2020

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