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Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Standard

Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study. / Næss-Schmidt, Erhard Trillingsgaard; Blicher, Jakob Udby; Tietze, Anna et al.
I: Brain Injury, Bind 32, Nr. 1, 2018, s. 91-98.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Næss-Schmidt, ET, Blicher, JU, Tietze, A, Rask, CU, Svendsen, SW, Schröder, A, Thastum, MM, Tuborgh, AH, Frederiksen, O-V, Østergaard, L, Eskildsen, SF, Hansen, B, Jespersen, S & Nielsen, JF 2018, 'Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study', Brain Injury, bind 32, nr. 1, s. 91-98. https://doi.org/10.1080/02699052.2017.1377352

APA

Næss-Schmidt, E. T., Blicher, J. U., Tietze, A., Rask, C. U., Svendsen, S. W., Schröder, A., Thastum, M. M., Tuborgh, A. H., Frederiksen, O-V., Østergaard, L., Eskildsen, S. F., Hansen, B., Jespersen, S., & Nielsen, J. F. (2018). Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study. Brain Injury, 32(1), 91-98. https://doi.org/10.1080/02699052.2017.1377352

CBE

Næss-Schmidt ET, Blicher JU, Tietze A, Rask CU, Svendsen SW, Schröder A, Thastum MM, Tuborgh AH, Frederiksen O-V, Østergaard L, et al. 2018. Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study. Brain Injury. 32(1):91-98. https://doi.org/10.1080/02699052.2017.1377352

MLA

Næss-Schmidt, Erhard Trillingsgaard et al. "Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study". Brain Injury. 2018, 32(1). 91-98. https://doi.org/10.1080/02699052.2017.1377352

Vancouver

Næss-Schmidt ET, Blicher JU, Tietze A, Rask CU, Svendsen SW, Schröder A et al. Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study. Brain Injury. 2018;32(1):91-98. Epub 2017 nov. 2. doi: 10.1080/02699052.2017.1377352

Author

Næss-Schmidt, Erhard Trillingsgaard ; Blicher, Jakob Udby ; Tietze, Anna et al. / Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study. I: Brain Injury. 2018 ; Bind 32, Nr. 1. s. 91-98.

Bibtex

@article{1a1ef72df80b497d85fce54199cf8dbe,
title = "Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study",
abstract = "PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.METHODS AND PROCEDURES: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. The patients were matched on age, sex and time since accident. Data from an external healthy control group (n = 27) was included.MAIN OUTCOME AND RESULTS: There was no difference in MKT between the two groups with mTBI and no correlation between MKT and PCS. There was no difference between the three groups in other diffusion measures.CONCLUSIONS: Our results did not point to microstructural changes in the corpus callosum, thalamus and hippocampus in relation to PCS after mTBI.",
keywords = "Journal Article, microstructure, Concussion, kurtosis, mild traumatic brain injury, RISK-FACTORS, KURTOSIS, COGNITIVE IMPAIRMENT, TRAUMATIC-BRAIN-INJURY, MILD, POSTCONCUSSIVE SYMPTOMS, WATER DIFFUSION, MINOR HEAD-INJURY, COHORT, QUESTIONNAIRE",
author = "N{\ae}ss-Schmidt, {Erhard Trillingsgaard} and Blicher, {Jakob Udby} and Anna Tietze and Rask, {Charlotte Ulrikka} and Svendsen, {Susanne Wulff} and Andreas Schr{\"o}der and Thastum, {Mille M{\o}ller} and Tuborgh, {Astrid H{\o}eg} and Oana-Veronica Frederiksen and Leif {\O}stergaard and Eskildsen, {Simon Fristed} and Brian Hansen and Sune Jespersen and Nielsen, {J{\o}rgen Feldb{\ae}k}",
year = "2018",
doi = "10.1080/02699052.2017.1377352",
language = "English",
volume = "32",
pages = "91--98",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Taylor & Francis ",
number = "1",

}

RIS

TY - JOUR

T1 - Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls - a cross sectional study

AU - Næss-Schmidt, Erhard Trillingsgaard

AU - Blicher, Jakob Udby

AU - Tietze, Anna

AU - Rask, Charlotte Ulrikka

AU - Svendsen, Susanne Wulff

AU - Schröder, Andreas

AU - Thastum, Mille Møller

AU - Tuborgh, Astrid Høeg

AU - Frederiksen, Oana-Veronica

AU - Østergaard, Leif

AU - Eskildsen, Simon Fristed

AU - Hansen, Brian

AU - Jespersen, Sune

AU - Nielsen, Jørgen Feldbæk

PY - 2018

Y1 - 2018

N2 - PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.METHODS AND PROCEDURES: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. The patients were matched on age, sex and time since accident. Data from an external healthy control group (n = 27) was included.MAIN OUTCOME AND RESULTS: There was no difference in MKT between the two groups with mTBI and no correlation between MKT and PCS. There was no difference between the three groups in other diffusion measures.CONCLUSIONS: Our results did not point to microstructural changes in the corpus callosum, thalamus and hippocampus in relation to PCS after mTBI.

AB - PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.METHODS AND PROCEDURES: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. The patients were matched on age, sex and time since accident. Data from an external healthy control group (n = 27) was included.MAIN OUTCOME AND RESULTS: There was no difference in MKT between the two groups with mTBI and no correlation between MKT and PCS. There was no difference between the three groups in other diffusion measures.CONCLUSIONS: Our results did not point to microstructural changes in the corpus callosum, thalamus and hippocampus in relation to PCS after mTBI.

KW - Journal Article

KW - microstructure

KW - Concussion

KW - kurtosis

KW - mild traumatic brain injury

KW - RISK-FACTORS

KW - KURTOSIS

KW - COGNITIVE IMPAIRMENT

KW - TRAUMATIC-BRAIN-INJURY

KW - MILD

KW - POSTCONCUSSIVE SYMPTOMS

KW - WATER DIFFUSION

KW - MINOR HEAD-INJURY

KW - COHORT

KW - QUESTIONNAIRE

U2 - 10.1080/02699052.2017.1377352

DO - 10.1080/02699052.2017.1377352

M3 - Journal article

C2 - 29095055

VL - 32

SP - 91

EP - 98

JO - Brain Injury

JF - Brain Injury

SN - 0269-9052

IS - 1

ER -