Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Carlota Castro-Espin; Catalina Bonet; Marta Crous-Bou; Verena Katzke; Charlotte Le Cornet; Franziska Jannasch; Matthias B Schulze; Anja Olsen; Anne Tjønneland; Christina C Dahm; Christian S Antoniussen; Maria Jose Sánchez; Pilar Amiano; María Dolores Chirlaque; Marcela Guevara; Claudia Agnoli; Rosario Tumino; Carlotta Sacerdote; Maria Santucci De Magistris; Malin Sund; Stina Bodén; Torill Enget Jensen; Karina Standahl Olsen; Guri Skeie; Marc J Gunter; Sabina Rinaldi; Esther M Gonzalez-Gil; Elisabete Weiderpass; Sofia Christakoudi; Alicia K Heath; Laure Dossus; Antonio Agudo

doi:10.1038/s41416-023-02169-2

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Carlota Castro-Espin, Catalina Bonet, Marta Crous-Bou, Verena Katzke, Charlotte Le Cornet, Franziska Jannasch, Matthias B Schulze, Anja Olsen, Anne Tjønneland, Christina C Dahm, Christian S Antoniussen, Maria Jose Sánchez, Pilar Amiano, María Dolores Chirlaque, Marcela Guevara, Claudia Agnoli, Rosario Tumino, Carlotta Sacerdote, Maria Santucci De Magistris, Malin SundStina Bodén, Torill Enget Jensen, Karina Standahl Olsen, Guri Skeie, Marc J Gunter, Sabina Rinaldi, Esther M Gonzalez-Gil, Elisabete Weiderpass, Sofia Christakoudi, Alicia K Heath, Laure Dossus, Antonio Agudo

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.

METHODS: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.

RESULTS: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.

CONCLUSIONS: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

Originalsprog	Engelsk
Tidsskrift	British Journal of Cancer
Vol/bind	128
Nummer	7
Sider (fra-til)	1301-1310
ISSN	0007-0920
DOI	https://doi.org/10.1038/s41416-023-02169-2
Status	Udgivet - mar. 2023

Adgang til dokumentet

10.1038/s41416-023-02169-2

Citationsformater

Castro-Espin, C., Bonet, C., Crous-Bou, M., Katzke, V., Le Cornet, C., Jannasch, F., Schulze, M. B., Olsen, A., Tjønneland, A., Dahm, C. C., Antoniussen, C. S., Sánchez, M. J., Amiano, P., Chirlaque, M. D., Guevara, M., Agnoli, C., Tumino, R., Sacerdote, C., De Magistris, M. S., ... Agudo, A. (2023). Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study. British Journal of Cancer, 128(7), 1301-1310. https://doi.org/10.1038/s41416-023-02169-2

@article{fe7f2fb028d8414c86a5746e9d0f92f9,

title = "Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study",

abstract = "BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.METHODS: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.RESULTS: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.CONCLUSIONS: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.",

keywords = "Breast Neoplasms/diagnosis, Cohort Studies, Diet, Estrogens, Female, Humans, Prospective Studies, Risk Factors",

author = "Carlota Castro-Espin and Catalina Bonet and Marta Crous-Bou and Verena Katzke and {Le Cornet}, Charlotte and Franziska Jannasch and Schulze, {Matthias B} and Anja Olsen and Anne Tj{\o}nneland and Dahm, {Christina C} and Antoniussen, {Christian S} and S{\'a}nchez, {Maria Jose} and Pilar Amiano and Chirlaque, {Mar{\'i}a Dolores} and Marcela Guevara and Claudia Agnoli and Rosario Tumino and Carlotta Sacerdote and {De Magistris}, {Maria Santucci} and Malin Sund and Stina Bod{\'e}n and Jensen, {Torill Enget} and Olsen, {Karina Standahl} and Guri Skeie and Gunter, {Marc J} and Sabina Rinaldi and Gonzalez-Gil, {Esther M} and Elisabete Weiderpass and Sofia Christakoudi and Heath, {Alicia K} and Laure Dossus and Antonio Agudo",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = mar,

doi = "10.1038/s41416-023-02169-2",

language = "English",

volume = "128",

pages = "1301--1310",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "7",

}

Castro-Espin, C, Bonet, C, Crous-Bou, M, Katzke, V, Le Cornet, C, Jannasch, F, Schulze, MB, Olsen, A, Tjønneland, A, Dahm, CC , Antoniussen, CS, Sánchez, MJ, Amiano, P, Chirlaque, MD, Guevara, M, Agnoli, C, Tumino, R, Sacerdote, C, De Magistris, MS, Sund, M, Bodén, S, Jensen, TE, Olsen, KS, Skeie, G, Gunter, MJ, Rinaldi, S, Gonzalez-Gil, EM, Weiderpass, E, Christakoudi, S, Heath, AK, Dossus, L & Agudo, A 2023, 'Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study', British Journal of Cancer, bind 128, nr. 7, s. 1301-1310. https://doi.org/10.1038/s41416-023-02169-2

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study. / Castro-Espin, Carlota; Bonet, Catalina; Crous-Bou, Marta et al.
I: British Journal of Cancer, Bind 128, Nr. 7, 03.2023, s. 1301-1310.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis

T2 - results from a cohort study

AU - Castro-Espin, Carlota

AU - Bonet, Catalina

AU - Crous-Bou, Marta

AU - Katzke, Verena

AU - Le Cornet, Charlotte

AU - Jannasch, Franziska

AU - Schulze, Matthias B

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Dahm, Christina C

AU - Antoniussen, Christian S

AU - Sánchez, Maria Jose

AU - Amiano, Pilar

AU - Chirlaque, María Dolores

AU - Guevara, Marcela

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - De Magistris, Maria Santucci

AU - Sund, Malin

AU - Bodén, Stina

AU - Jensen, Torill Enget

AU - Olsen, Karina Standahl

AU - Skeie, Guri

AU - Gunter, Marc J

AU - Rinaldi, Sabina

AU - Gonzalez-Gil, Esther M

AU - Weiderpass, Elisabete

AU - Christakoudi, Sofia

AU - Heath, Alicia K

AU - Dossus, Laure

AU - Agudo, Antonio

PY - 2023/3

Y1 - 2023/3

N2 - BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.METHODS: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.RESULTS: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.CONCLUSIONS: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

AB - BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.METHODS: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.RESULTS: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.CONCLUSIONS: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

KW - Breast Neoplasms/diagnosis

KW - Cohort Studies

KW - Diet

KW - Estrogens

KW - Female

KW - Humans

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1038/s41416-023-02169-2

DO - 10.1038/s41416-023-02169-2

M3 - Journal article

C2 - 36737658

SN - 0007-0920

VL - 128

SP - 1301

EP - 1310

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 7

ER -

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater