Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Marinka Steur, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Storbritannien
  • Laura Johnson, Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Senate House, Tyndall Ave, Bristol BS8 1TH, UK., Storbritannien
  • Stephen J Sharp, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Storbritannien
  • Fumiaki Imamura, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Storbritannien
  • Ivonne Sluijs, Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht University Utrecht The Netherlands, Holland
  • Timothy J Key, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Angela Wood, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Storbritannien
  • Rajiv Chowdhury, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Storbritannien
  • Marcela Guevara, Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain., Spanien
  • Marianne U Jakobsen, National Food Institute, Division for Diet, Disease Prevention and Toxicology, Technical University of Denmark, Kongens Lyngby, Denmark.
  • ,
  • Ingegerd Johansson, Department of Odontology, Cariology, Umeå University, Umeå, Sweden., Sverige
  • Albert Koulman, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, Cambridge, UK., Storbritannien
  • Kim Overvad
  • Maria-José Sánchez, Andalusian School of Public Health (EASP), Granada, Instituto de Investigación Biosanitaria (ibs.GRANADA), CIBER of Epidemiology and Public Health (CIBERESP) Madrid, Universidad de Granada, Spanien
  • Yvonne T van der Schouw, Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht University Utrecht The Netherlands, Holland
  • Antonia Trichopoulou, Hellenic Health Foundation (HHF), Athens, Greece., Grækenland
  • Elisabete Weiderpass, International Agency for Research on CancerWorld Health Organization Lyon France, Frankrig
  • Maria Wennberg, Section of Sustainable Health Department of Public Health and Clinical Medicine Umeå University Umeå Sweden, Sverige
  • Ju-Sheng Zheng, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., School of Life Sciences Westlake University Hangzhou, Storbritannien
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Postdam, Germany., Tyskland
  • Jolanda M A Boer, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Holland
  • Marie-Christine Boutron-Ruault, Le Centre de recherche en Epidémiologie et Santé des Populations (CESP) Faculté de médecine - Univ. Paris-SudFaculté de Médecine-UVSQINSERMUniversité Paris-Saclay Villejuif France, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Ulrika Ericson, Diabetes and Cardiovascular disease Genetic Epidemiology Department of Clinical Sciences in Malmö Lund University Malmö Sweden, Sverige
  • Alicia K Heath, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Storbritannien
  • Inge Huybrechts, International Agency for Research on CancerWorld Health Organization Lyon France, Frankrig
  • Liher Imaz, Ministry of Health of the Basque GovernmentPublic Health Division of Gipuzkoa Donostia-San Sebastian Spain, Biodonostia Health Research Institute Donostia-San Sebastian, Spanien
  • Rudolf Kaaks, Division of Cancer EpidemiologyGerman Cancer Research Center (DKFZ) Heidelberg Germany, Tyskland
  • Vittorio Krogh, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Tilman Kühn, Division of Cancer EpidemiologyGerman Cancer Research Center (DKFZ) Heidelberg Germany, Tyskland
  • Cecilie Kyrø, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Giovanna Masala, Cancer Risk Factors and Life-Style Epidemiology UnitInstitute for Cancer Research, Italien
  • Olle Melander, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sverige
  • Conchi Moreno-Iribas, Navarra Public Health Institute, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Research Network on Health Services in Chronic Diseases (REDISSEC) Pamplona, Spanien
  • Salvatore Panico, Dipartmento Di Medicina Clinica E Chiorurgia Federcio II University Naples Italy, Italien
  • José R Quirós, Public Health Directorate, Asturias, Spain., Spanien
  • Miguel Rodríguez-Barranco, CIBER of Epidemiology and Public Health (CIBERESP) Madrid, Andalusian School of Public Health (EASP), Granada, Instituto de Investigación Biosanitaria (ibs.GRANADA), Spanien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Carmen Santiuste, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Spanien
  • Guri Skeie, Department of Community Medicine University of TromsøThe Arctic University of Norway Tromsø Norway, Norge
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Danmark
  • Rosario Tumino, Cancer Registry and Histopathology Department, Azienda Sanitaria Provinciale (ASP) Ragusa, Italy., Associazione Iblea Ricerca Epidemiologica (A.I.R.E. - ONLUS) Ragusa, Italien
  • W M Monique Verschuren, Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht University Utrecht The Netherlands, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Holland
  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Christina C Dahm
  • Aurora Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Matthias B Schulze, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Tyskland
  • Tammy Y N Tong, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Storbritannien
  • Nicholas J Wareham, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Storbritannien
  • John Danesh, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., BHF Centre of Research Excellence University of Cambridge, NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., HDR UK CambridgeWellcome Genome Campus and University of Cambridge, Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Storbritannien
  • Adam S Butterworth, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., BHF Centre of Excellence and the Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., HDR UK CambridgeWellcome Genome Campus and University of Cambridge, Storbritannien
  • Nita G Forouhi, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Storbritannien

Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.

OriginalsprogEngelsk
Artikelnummere019814
TidsskriftJournal of the American Heart Association
Vol/bind10
Nummer23
Antal sider37
ISSN2047-9980
DOI
StatusUdgivet - dec. 2021

Se relationer på Aarhus Universitet Citationsformater

ID: 226789202