Dietary and circulating fatty acids and ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

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  • Sahar Yammine, International Agency for Research on Cancer, Frankrig
  • Inge Huybrechts, International Agency for Research on Cancer, Frankrig
  • Carine Biessy, International Agency for Research on Cancer, Frankrig
  • Laure Dossus, International Agency for Research on Cancer, Frankrig
  • Elom K Aglago, International Agency for Research on Cancer, Frankrig
  • Sabine Naudin, International Agency for Research on Cancer, Frankrig
  • Pietro Ferrari, International Agency for Research on Cancer, Frankrig
  • Elisabete Weiderpass, International Agency for Research on Cancer
  • ,
  • Anne Tjonneland, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Danmark
  • Louise Hansen, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Danmark
  • Kim Overvad
  • Francesca Romana Mancini, Health across Generations Team, Inserm U1018, Gustave Roussy., Frankrig
  • Marie-Christine Boutron-Ruault, Health across Generations Team, Inserm U1018, Gustave Roussy., Frankrig
  • Marina Kvaskoff, Health across Generations Team, Inserm U1018, Gustave Roussy., Frankrig
  • Renée Turzanski Fortner, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg , Tyskland
  • Rudolf Kaaks, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg , Tyskland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Heiner Boing, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Antonia Trichopoulou, Hellenic Health Foundation., Grækenland
  • Anna Karakatsani, Hellenic Health Foundation., Grækenland
  • Carlo La Vecchia, University of Milan, Milan, Italy, Italien
  • Vassiliki Benetou, National and Kapodistrian University of Athens, Grækenland
  • Giovanna Masala, Institute for Cancer Research, Italien
  • Vittorio Krogh, Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori., Italien
  • Amalia Mattiello, Univ Naples Federico II, University of Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Italien
  • Alessandra Macciotta, Polytechnic University of Turin, Italien
  • Inger T Gram, University of Tromsø, Tromsø, Norge
  • Guri Skeie, UiT - The Arctic University of Norway, Tromsø Museum, Tromsø, Norway., Norge
  • Jose Ramon Quiros Garcia, EPIC Asturias, Public Health Directorate, Asturias, 33006 Oviedo, Spain. joseramon.quirosgarcia@asturias.org., Spanien
  • Antonio Agudo, Medical Oncology, Catalan Institute of Oncology, IDIBELL., Spanien
  • Maria-Jose Sanchez-Perez, Andalusian School of Public Health, Granada, Spain., Spanien
  • Maria-Dolores Chirlaque, Universidad Católica San Antonio de Murcia, Spanien
  • Eva Ardanaz, Navarra Public Health Institute, Spanien
  • Leire Gil, Biodonostia Health Research Institute, Spanien
  • Hanna Sartor, Skåne University Hospital, Lund, Sverige
  • Isabel Drake, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden., Sverige
  • Annika Idahl, Umea Univ, Umea University, Umea Ctr Funct Brain Imaging, Sverige
  • Eva A Lundin, Umea Univ, Umea University, Umea Ctr Funct Brain Imaging, Sverige
  • Dagfinn Aune, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, Storbritannien
  • Heather A Ward, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, Storbritannien
  • Melissa A Merritt, University of Hawaii Cancer Center, Honolulu, Hawaii., USA
  • Naomi E Allen, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Storbritannien
  • Marc J Gunter, WHO
  • ,
  • Veronique Chajes, International Agency For Research On Cancer chajesv@iarc.fr., Frankrig

BACKGROUND: Fatty acids impact obesity, estrogens and inflammation, risk factors for ovarian cancer. Few epidemiological studies have investigated the association of fatty acids with ovarian cancer.

METHODS: Within the European Prospective Investigation into Cancer and nutrition, 1,486 incident ovarian cancer cases were identified. Cox Proportional Hazard models with adjustment for ovarian cancer risk factors were used to estimate hazard ratios of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate odds ratios of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis.

RESULTS: A positive association was found between ovarian cancer and intake of industrial trans elaidic acid (Hazard Ratio comparing 5th with 1st quintileQ5-Q1=1.29; 95% CI=1.03-1.62; ptrend=0.02, q-value=0.06). Dietary intakes of n-6 linoleic acid (HRQ5-Q1=1.10; 95% CI=1.01-1.21; ptrend=0.03) and n-3 α-linolenic acid (HRQ5-Q1=1.18; 95% CI=1.05-1.34; ptrend=0.007) from deep frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (Odds Ratio comparing 3rd with 1st tertileT3-T1 = 1.39; 95% CI=0.99-1.94; ptrend=0.06) and α-linolenic acids (ORT3-T1=1.30; 95% CI=0.98-1.72; ptrend=0.06).

CONCLUSIONS: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and α-linolenic acid from deep frying fat, may be associated with greater risk of ovarian cancer.

IMPACT: If causal, eliminating industrial trans fatty acids could offer a straightforward public health action for reducing ovarian cancer.

OriginalsprogEngelsk
Artikelnummercebp.1477
TidsskriftCancer Epidemiology, Biomarkers & Prevention
Vol/bind29
Nummer9
Sider (fra-til)1739-1749
Antal sider11
ISSN1055-9965
DOI
StatusUdgivet - sep. 2020

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Copyright ©2020, American Association for Cancer Research.

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