diCal-IBD: demography-aware inference of identity-by-descent tracts in unrelated individuals

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Paula Tataru, Danmark
  • Jasmine A Nirody, Biophysics Graduate Group, University of California, Berkeley, CA, 94709, USA
  • Yun S Song, Computer Science Division, University of California, Berkeley, CA, 94709, USA
Summary: We present a tool, diCal-IBD, for detecting identity-bydescent (IBD) tracts between pairs of genomic sequences. Our method builds on a recent demographic inference method based on the coalescent with recombination, and is able to incorporate demographic information as a prior. Simulation study shows that diCal-IBD has significantly higher recall and precision than that of existing SNP-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as small as 0.1 cM.
Availability: http://sourceforge.net/projects/dical-ibd
Contact: yss@eecs.berkeley.edu
Supplementary Information: Available at the journal’s website.
OriginalsprogEngelsk
TidsskriftBioinformatics
Vol/bind30
Nummer23
Sider (fra-til) 3430-3431
Antal sider2
ISSN1367-4803
DOI
StatusUdgivet - 21 aug. 2014

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