diCal-IBD: demography-aware inference of identity-by-descent tracts in unrelated individuals

TY - JOUR

T1 - diCal-IBD: demography-aware inference of identity-by-descent tracts in unrelated individuals

AU - Tataru, Paula

AU - Nirody, Jasmine A

AU - Song, Yun S

PY - 2014/8/21

Y1 - 2014/8/21

N2 - Summary: We present a tool, diCal-IBD, for detecting identity-bydescent (IBD) tracts between pairs of genomic sequences. Our method builds on a recent demographic inference method based on the coalescent with recombination, and is able to incorporate demographic information as a prior. Simulation study shows that diCal-IBD has significantly higher recall and precision than that of existing SNP-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as small as 0.1 cM.Availability: http://sourceforge.net/projects/dical-ibdContact: [email protected] Information: Available at the journal’s website.

AB - Summary: We present a tool, diCal-IBD, for detecting identity-bydescent (IBD) tracts between pairs of genomic sequences. Our method builds on a recent demographic inference method based on the coalescent with recombination, and is able to incorporate demographic information as a prior. Simulation study shows that diCal-IBD has significantly higher recall and precision than that of existing SNP-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as small as 0.1 cM.Availability: http://sourceforge.net/projects/dical-ibdContact: [email protected] Information: Available at the journal’s website.

U2 - 10.1093/bioinformatics/btu563

DO - 10.1093/bioinformatics/btu563

M3 - Journal article

C2 - 25147361

SN - 1367-4803

VL - 30

SP - 3430

EP - 3431

JO - Bioinformatics

JF - Bioinformatics

IS - 23

ER -