TY - JOUR
T1 - Diagnostic and Prognostic Value of H-ficolin for Functionally Relevant Coronary Artery Disease
AU - Isayeva, Ganna
AU - Potlukova, Eliska
AU - Rumora, Klara
AU - Lopez Ayala, Pedro
AU - Kurun, Atakan
AU - Leibfarth, Jan-Philipp
AU - Schäfer, Ibrahim
AU - Michel, Evita
AU - Pesen, Kaan
AU - Zellweger, Michael J
AU - Trendelenburg, Marten
AU - Korsgaard Hejlesen, Trine
AU - Gudmann Hansen, Annette
AU - Thiel, Steffen
AU - Mueller, Christian
N1 - Copyright © 2023. Published by Elsevier B.V.
PY - 2023/11
Y1 - 2023/11
N2 - BACKGROUND: We aimed to test the diagnostic and prognostic ability of H-ficolin, an initiator of the lectin pathway of the complement system, for functionally relevant coronary artery disease (fCAD), and explore its determinants.METHODS: The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography and coronary angiography. H-ficolin levels were measured by a sandwich-type immunoassay at rest, peak stress-test, and 2h after stress-test. Cardiovascular death and non-fatal myocardial infarction were assessed during 5-year follow-up.RESULTS: Among 1,571 patients (32.3% women), fCAD was detected in 462 patients (29.4%). H-ficolin concentration at rest was 18.6 (15.3-21.8) µg/ml in patients with fCAD versus 17.8 (15.4-21.5) µg/ml, p=0.33, in patients without fCAD, resulting in an AUC of 0.53 (95%CI 0.48-0.56). During follow-up, 107 patients (6.8%) had non-fatal myocardial infarction and 99 patients (6.3%) experienced cardiovascular death. In Cox regression analysis, H-ficolin was not a predictor of events in the overall cohort. Subgroup analysis suggested a potential link between H-ficolin and non-fatal myocardial infarction in patients without fCAD (adjusted HR 1.03, 95% CI 1.02-1.15, p=0.005). H-ficolin concentration showed a weak positive correlation with systolic (r=0.069, p<0.001) and diastolic blood pressure (r=0.111, p<0.001).CONCLUSION: H-ficolin concentration did not have diagnostic and/or prognostic value in patients referred for fCAD work-up.
AB - BACKGROUND: We aimed to test the diagnostic and prognostic ability of H-ficolin, an initiator of the lectin pathway of the complement system, for functionally relevant coronary artery disease (fCAD), and explore its determinants.METHODS: The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography and coronary angiography. H-ficolin levels were measured by a sandwich-type immunoassay at rest, peak stress-test, and 2h after stress-test. Cardiovascular death and non-fatal myocardial infarction were assessed during 5-year follow-up.RESULTS: Among 1,571 patients (32.3% women), fCAD was detected in 462 patients (29.4%). H-ficolin concentration at rest was 18.6 (15.3-21.8) µg/ml in patients with fCAD versus 17.8 (15.4-21.5) µg/ml, p=0.33, in patients without fCAD, resulting in an AUC of 0.53 (95%CI 0.48-0.56). During follow-up, 107 patients (6.8%) had non-fatal myocardial infarction and 99 patients (6.3%) experienced cardiovascular death. In Cox regression analysis, H-ficolin was not a predictor of events in the overall cohort. Subgroup analysis suggested a potential link between H-ficolin and non-fatal myocardial infarction in patients without fCAD (adjusted HR 1.03, 95% CI 1.02-1.15, p=0.005). H-ficolin concentration showed a weak positive correlation with systolic (r=0.069, p<0.001) and diastolic blood pressure (r=0.111, p<0.001).CONCLUSION: H-ficolin concentration did not have diagnostic and/or prognostic value in patients referred for fCAD work-up.
KW - Functionally relevant coronary artery disease
KW - H-ficolin
KW - The complement immune system
UR - http://www.scopus.com/inward/record.url?scp=85173270227&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2023.117582
DO - 10.1016/j.cca.2023.117582
M3 - Journal article
C2 - 37802208
SN - 0009-8981
VL - 551
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
M1 - 117582
ER -