TY - JOUR
T1 - Diabetic polyneuropathy and pain, prevalence, and patient characteristics
T2 - a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes
AU - Gylfadottir, Sandra Sif
AU - Christensen, Diana Hedevang
AU - Nicolaisen, Sia Kromann
AU - Andersen, Henning
AU - Callaghan, Brian Christopher
AU - Itani, Mustapha
AU - Khan, Karolina Snopek
AU - Kristensen, Alexander Gramm
AU - Nielsen, Jens Steen
AU - Sindrup, Søren Hein
AU - Andersen, Niels Trolle
AU - Jensen, Troels Staehelin
AU - Thomsen, Reimar Wernich
AU - Finnerup, Nanna Brix
PY - 2020
Y1 - 2020
N2 - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.
AB - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.
KW - COMPLICATIONS
KW - DEPRESSION
KW - EMOTIONAL DISTRESS
KW - EPIDEMIOLOGY
KW - Mental health
KW - NEUROPATHIC PAIN
KW - Neuropathic pain
KW - PERIPHERAL NEUROPATHY
KW - PHENOTYPE
KW - POPULATION
KW - Painful diabetic polyneuropathy
KW - Patient characteristics
KW - Polyneuropathy
KW - Prevalence
KW - QUALITY-OF-LIFE
KW - Quality of life
KW - RISK-FACTORS
UR - http://www.scopus.com/inward/record.url?scp=85079352700&partnerID=8YFLogxK
U2 - 10.1097/j.pain.0000000000001744
DO - 10.1097/j.pain.0000000000001744
M3 - Journal article
C2 - 31693539
SN - 0304-3959
VL - 161
SP - 574
EP - 583
JO - Pain
JF - Pain
IS - 3
ER -