Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia

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  • Stine Byberg, Bandim Health Project, Statens Serum Institut, Steno Diabetes Center, Copenhagen
  • ,
  • Camilla Bundesen, Bandim Health Project, Odense University Hospital
  • ,
  • Frauke Rudolf, Bandim Health Project
  • ,
  • Thorny Linda Haraldsdottir, Bandim Health Project
  • ,
  • Lamine Indjai, The National Diabetes Association
  • ,
  • Rui Barai, The National Diabetes Association
  • ,
  • Henning Beck-Nielsen, Odense University Hospital
  • ,
  • Morten Sodemann, Bandim Health Project, Odense University Hospital
  • ,
  • Dorte Møller Jensen, Odense University Hospital
  • ,
  • Morten Bjerregaard-Andersen, Bandim Health Project, Statens Serum Institut, Hospital of Southwest Denmark, Odense University Hospital

Background: The burden of diabetes mellitus in Sub-Saharan Africa is growing rapidly, and yet the prevalence and patient characteristics are still largely unknown. Objectives: We analyzed clinical and demographic characteristics of Type 2 diabetes (T2DM) patients attending a diabetes clinic in Guinea-Bissau from February 2008 to April 2014, and estimated the prevalence and risk factors of unknown-impaired fasting plasma glucose (FPG) and diabetes, as well as excess mortality associated with T2DM. Methods: We characterized T2DM patients attending the national diabetes clinic in Bissau. Diabetes was diagnosed based on FPG. We matched T2DM patients 1:1 with non-diabetes community controls on age and sex to determine relevant risk factors for T2DM using logistic regression. Furthermore, we matched patients 1:6 with community controls to assess long-term survival (until February 2019) in a Cox regression using calendar time as the underlying timescale. Verbal autopsies determined the cause of death among T2DM patients and controls. Results: The mean age among T2DM was 50.6 (SD 11.1), and the mean FPG at first consultation was high (13.2 mmol/L (SD 5.1)). Ethnicity, family history of diabetes, hypertension, and anthropometrics differed among T2DM patients, community controls with impaired FPG, and healthy controls. Family history of diabetes (OR = 5.65, 95% CI: 3.10–10.3) and elevated waist circumference (2.33, 1.26–4.29) were significant risk factors for T2DM. 20.4% (59/289) of community controls had abnormal FPG. T2DM patients had an excess mortality hazard ratio of 3.53 (95%CI: 1.92–6.52). Deaths caused by bacterial infections, including foot ulcers, were more common among T2DM patients, compared with community controls (54% (7/13) vs. 19% (5/27) (P = 0.02)). Conclusion: Several risk factors including were associated with T2DM in Guinea-Bissau. We found a high prevalence of elevated FPG among randomly selected community controls. In combination with higher mortality among T2DM patients, an urgent need for better treatment options and increased awareness.

OriginalsprogEngelsk
Artikelnummer1802136
TidsskriftGlobal Health Action
Vol/bind13
Nummer1
Antal sider11
ISSN1654-9880
DOI
StatusUdgivet - 2020

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