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Development and validation of a fast gas chromatography mass spectrometry method for the quantification of selected non- intentionally added substances and polystyrene/polyurethane oligomers in liquid food simulants

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  • Emmanouil Tsochatzis, Center for Interdisciplinary Research and Innovation (CIRI-AUTH)
  • ,
  • Helen Gika, Aristotle University of Thessaloniki, Center for Interdisciplinary Research and Innovation (CIRI-AUTH)
  • ,
  • Georgios Theodoridis, Aristotle University of Thessaloniki, Center for Interdisciplinary Research and Innovation (CIRI-AUTH)
A simple, fast, sensitive and reliable method was developed for the simultaneous determination of 13 food contact materials (FCM) regulated substances and non-intentionally added substances (NIAS) migrating into official food simulants. The method has been optimized to quantify the monomers styrene and a-methyl styrene, selected polystyrene oligomers (dimers, trimers) and polyester urethane-based oligomers (PU) cyclic oligomers, as well as cyclic NIAS originating from food packaging such as 2,6-Di- tert-butylbenzoquinone and 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione.
The method employs liquid-liquid extraction of aqueous ethanol food simulants with dichloro- methane, and analysis with gas chromatography coupled to mass spectrometry (GC-MS) with a total analysis time of less than 16 min, with limits of detections ranging from 0.32 ng mL1 (1,1-diphenyl- ethylene) to 14.8 ng mL1 for 7,9-di-tert-butyl-1-oxaspiro[4.5]deca-6,9-diene-2,8-dione and respective limits of quantification from 1.0 ng mL1 to 41.7 ng mL1, for the same analytes.
Accuracy and precision results showed that the method is sufficiently accurate for all target analytes, with recoveries ranging between 80 and 110% and relative standard deviations (RSDs) smaller than 16% at the three selected concentration levels.
TidsskriftAnalytica Chimica Acta
Sider (fra-til)49-59
Antal sider11
StatusUdgivet - 2020

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