Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Eva Sonnenberg-Riethmacher; Michaela Miehe; Claus C. Stolt; Derk E. Goerich; Michael Wegner; Dieter Riethmacher

Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Eva Sonnenberg-Riethmacher, Michaela Miehe, Claus C. Stolt, Derk E. Goerich, Michael Wegner, Dieter Riethmacher

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

92 Citationer (Scopus)

Abstract

Abstract
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

Originalsprog	Engelsk
Tidsskrift	Mechanisms of Development
Vol/bind	109
Nummer	2
Sider (fra-til)	253
Antal sider	265
ISSN	0925-4773
Status	Udgivet - dec. 2001

Tjek tilgængelighed hos det Kgl. Bibliotek

Citationsformater

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title = "Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10",

abstract = "AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.",

author = "Eva Sonnenberg-Riethmacher and Michaela Miehe and Stolt, {Claus C.} and Goerich, {Derk E.} and Michael Wegner and Dieter Riethmacher",

year = "2001",

month = dec,

language = "English",

volume = "109",

pages = "253",

journal = "Mechanisms of Development",

issn = "0925-4773",

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Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. / Sonnenberg-Riethmacher, Eva; Miehe, Michaela; Stolt, Claus C. et al.
I: Mechanisms of Development, Bind 109, Nr. 2, 12.2001, s. 253.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

AU - Sonnenberg-Riethmacher, Eva

AU - Miehe, Michaela

AU - Stolt, Claus C.

AU - Goerich, Derk E.

AU - Wegner, Michael

AU - Riethmacher, Dieter

PY - 2001/12

Y1 - 2001/12

N2 - AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

AB - AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

M3 - Journal article

SN - 0925-4773

VL - 109

SP - 253

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 2

ER -

Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Abstract

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