Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods : MScanFit MUNE and muscle velocity recovery cycles. / Witt, A.; Fuglsang-Frederiksen, A.; Finnerup, N. B. et al.
I: Clinical Neurophysiology, Bind 131, Nr. 10, 10.2020, s. 2383-2392.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods
T2 - MScanFit MUNE and muscle velocity recovery cycles
AU - Witt, A.
AU - Fuglsang-Frederiksen, A.
AU - Finnerup, N. B.
AU - Kasch, H.
AU - Tankisi, H.
PY - 2020/10
Y1 - 2020/10
N2 - Objective: To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2) muscle velocity recovery cycles (MVRCs) measuring muscle membrane properties which has previously shown depolarization of the muscle membrane in denervated muscles. Methods: Thirty chronic SCI patients (lesion above Th10) and twenty-five gender –and age matched healthy controls (HC) were examined. MScanFit was recorded from peroneal nerve to anterior tibial muscle (TA) and tibial nerve to abductor hallucis muscle after excluding localized mononeuropathies. MVRCs were recorded from TA. Results: Nerve conduction studies showed mononeuropathy in 8 patients (27%) (sciatic (2), -or peroneal nerve (6)). SCI patients had in average reduced motor unit number compared with HC and prolonged muscle refractory period and reduced supernormality. Significance: A high prevalence of nerve lesion and a diffuse affection of the PNS following SCI are highly relevant findings that should be accounted for when planning neurorehabilitation for persons living with SCI.
AB - Objective: To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2) muscle velocity recovery cycles (MVRCs) measuring muscle membrane properties which has previously shown depolarization of the muscle membrane in denervated muscles. Methods: Thirty chronic SCI patients (lesion above Th10) and twenty-five gender –and age matched healthy controls (HC) were examined. MScanFit was recorded from peroneal nerve to anterior tibial muscle (TA) and tibial nerve to abductor hallucis muscle after excluding localized mononeuropathies. MVRCs were recorded from TA. Results: Nerve conduction studies showed mononeuropathy in 8 patients (27%) (sciatic (2), -or peroneal nerve (6)). SCI patients had in average reduced motor unit number compared with HC and prolonged muscle refractory period and reduced supernormality. Significance: A high prevalence of nerve lesion and a diffuse affection of the PNS following SCI are highly relevant findings that should be accounted for when planning neurorehabilitation for persons living with SCI.
KW - Spinal cord injury
KW - Motor unit number estimation
KW - Peripheral nervous system
KW - Muscle velocity recovery cycles
KW - Spasticity
KW - UNIT NUMBER ESTIMATION
KW - AMYOTROPHIC-LATERAL-SCLEROSIS
KW - DENERVATION
KW - DYSFUNCTION
KW - STROKE
U2 - 10.1016/j.clinph.2020.06.032
DO - 10.1016/j.clinph.2020.06.032
M3 - Journal article
C2 - 32828041
VL - 131
SP - 2383
EP - 2392
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 10
ER -