Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles

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Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods : MScanFit MUNE and muscle velocity recovery cycles. / Witt, A.; Fuglsang-Frederiksen, A.; Finnerup, N. B. et al.

I: Clinical Neurophysiology, Bind 131, Nr. 10, 10.2020, s. 2383-2392.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{de1eed9e92c3447e96149d00b8a1b56d,
title = "Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles",
abstract = "Objective: To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2) muscle velocity recovery cycles (MVRCs) measuring muscle membrane properties which has previously shown depolarization of the muscle membrane in denervated muscles. Methods: Thirty chronic SCI patients (lesion above Th10) and twenty-five gender –and age matched healthy controls (HC) were examined. MScanFit was recorded from peroneal nerve to anterior tibial muscle (TA) and tibial nerve to abductor hallucis muscle after excluding localized mononeuropathies. MVRCs were recorded from TA. Results: Nerve conduction studies showed mononeuropathy in 8 patients (27%) (sciatic (2), -or peroneal nerve (6)). SCI patients had in average reduced motor unit number compared with HC and prolonged muscle refractory period and reduced supernormality. Significance: A high prevalence of nerve lesion and a diffuse affection of the PNS following SCI are highly relevant findings that should be accounted for when planning neurorehabilitation for persons living with SCI.",
keywords = "Spinal cord injury, Motor unit number estimation, Peripheral nervous system, Muscle velocity recovery cycles, Spasticity, UNIT NUMBER ESTIMATION, AMYOTROPHIC-LATERAL-SCLEROSIS, DENERVATION, DYSFUNCTION, STROKE",
author = "A. Witt and A. Fuglsang-Frederiksen and Finnerup, {N. B.} and H. Kasch and H. Tankisi",
year = "2020",
month = oct,
doi = "10.1016/j.clinph.2020.06.032",
language = "English",
volume = "131",
pages = "2383--2392",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods

T2 - MScanFit MUNE and muscle velocity recovery cycles

AU - Witt, A.

AU - Fuglsang-Frederiksen, A.

AU - Finnerup, N. B.

AU - Kasch, H.

AU - Tankisi, H.

PY - 2020/10

Y1 - 2020/10

N2 - Objective: To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2) muscle velocity recovery cycles (MVRCs) measuring muscle membrane properties which has previously shown depolarization of the muscle membrane in denervated muscles. Methods: Thirty chronic SCI patients (lesion above Th10) and twenty-five gender –and age matched healthy controls (HC) were examined. MScanFit was recorded from peroneal nerve to anterior tibial muscle (TA) and tibial nerve to abductor hallucis muscle after excluding localized mononeuropathies. MVRCs were recorded from TA. Results: Nerve conduction studies showed mononeuropathy in 8 patients (27%) (sciatic (2), -or peroneal nerve (6)). SCI patients had in average reduced motor unit number compared with HC and prolonged muscle refractory period and reduced supernormality. Significance: A high prevalence of nerve lesion and a diffuse affection of the PNS following SCI are highly relevant findings that should be accounted for when planning neurorehabilitation for persons living with SCI.

AB - Objective: To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2) muscle velocity recovery cycles (MVRCs) measuring muscle membrane properties which has previously shown depolarization of the muscle membrane in denervated muscles. Methods: Thirty chronic SCI patients (lesion above Th10) and twenty-five gender –and age matched healthy controls (HC) were examined. MScanFit was recorded from peroneal nerve to anterior tibial muscle (TA) and tibial nerve to abductor hallucis muscle after excluding localized mononeuropathies. MVRCs were recorded from TA. Results: Nerve conduction studies showed mononeuropathy in 8 patients (27%) (sciatic (2), -or peroneal nerve (6)). SCI patients had in average reduced motor unit number compared with HC and prolonged muscle refractory period and reduced supernormality. Significance: A high prevalence of nerve lesion and a diffuse affection of the PNS following SCI are highly relevant findings that should be accounted for when planning neurorehabilitation for persons living with SCI.

KW - Spinal cord injury

KW - Motor unit number estimation

KW - Peripheral nervous system

KW - Muscle velocity recovery cycles

KW - Spasticity

KW - UNIT NUMBER ESTIMATION

KW - AMYOTROPHIC-LATERAL-SCLEROSIS

KW - DENERVATION

KW - DYSFUNCTION

KW - STROKE

U2 - 10.1016/j.clinph.2020.06.032

DO - 10.1016/j.clinph.2020.06.032

M3 - Journal article

C2 - 32828041

VL - 131

SP - 2383

EP - 2392

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 10

ER -