Deep Eutectic Solvents as Efficient Solvents in Biocatalysis

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  • Magdalena Pätzold, DECHEMA Research Institute, Frankfurt, Technische Universitat Hamburg
  • ,
  • Sascha Siebenhaller, Karlsruhe Institute of Technology, Karlsruhe
  • ,
  • Selin Kara
  • Andreas Liese, Hamburg University of Technology
  • ,
  • Christoph Syldatk, Karlsruhe Institute of Technology, Karlsruhe
  • ,
  • Dirk Holtmann, DECHEMA Research Institute, Frankfurt

‘Ideal’ solvents in biocatalysis have to fulfill a large number of requirements, such as high substrate solubility, high enzyme activity and stability, and positive effects on reaction equilibrium. In the past decades, many enzymatic synthesis routes in water-based and nonaqueous (organic solvents, ionic or supercritical fluids) reaction media have been developed. However, no solvent meets every demand for different reaction types at the same time, and there is still a need for novel solvents suited for different reaction types and applications. Deep eutectic solvents (DESs) have recently been evaluated as solvents in different biocatalytic reactions. They can improve substrate supply, conversion, and stability. The best results were obtained when the DES is formed by the substrates of an enzymatic reaction.

TidsskriftTrends in Biotechnology
Sider (fra-til)943-959
Antal sider17
StatusUdgivet - 1 sep. 2019

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