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Deconstructing glucagon fibrillation: Biophysical investigations of glucagon fibrillation pathway and fibril polymorphism

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Shirin Ghodke, Danmark
  • Molekylærbiologisk Institut
  • Interdisciplinær Nanoscience Forskerskole
Aggregation of misfolded proteins into ordered amyloid fibrils has deep implications in disease pathology as well as in pharmaceutical production of therapeutic proteins. This thesis elucidates the fibrillation pathway of the therapeutic peptide hormone, glucagon and explores the biophysical basis of its inherent fibril polymorphism by varying physicochemical factors like temperature, pressure and co-solvents. This work demonstrates the important role of hydration in the fibrillation process as well as in fibril polymorphism.
OriginalsprogEngelsk
ForlagAarhus Universitet
Antal sider182
StatusUdgivet - 2011

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