Decline in severe spastic cerebral palsy at term in Denmark 1999–2007

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DOI

  • Christina Engel Hoei-Hansen, Rigshospitalet
  • ,
  • Bjarne Laursen, Syddansk Universitet
  • ,
  • Jens Langhoff-Roos, Rigshospitalet
  • ,
  • Gija Rackauskaite
  • Peter Uldall, Rigshospitalet

Aim: To analyse trends in prevalence and severity of cerebral palsy (CP) in Denmark in birth years 1999–2007 and compare with previous periods. Method: Data has been collected uniformly in the Danish cerebral palsy national register nationwide since 1995. Rates in the time periods 1999–2001, 2002–2004 and 2005–2007 covering 585,393 births were analysed by gestational age and subtypes. Results: Total number of CP cases in the period was 1165. The overall prevalence of CP decreased significantly from 2.1 in 1999–2001 to 1.8 in 2005–2007 per 1000 livebirths (p = 0.022). The decline was only significant for children born at term (p = 0.007) but not for the preterm (p = 0.44). The decline in children born at term was based on a decrease in bilateral spastic CP (n = 117 in years 1999–2001 and n = 59 in 2005–2007). Multidisciplinary obstetric skills training with neonatal resuscitation in Denmark was initiated in 2003 and timely associated with the decrease. The prevalence of unilateral spastic CP the prevalence did not change, but in the two last time periods more children had a right-sided than left-sided unilateral spastic CP. Conclusion: The decline in rate of CP seen in 2005–2007 as compared to 1999–2001 was mainly based on fewer cases of severe spastic CP in term infants. We hypothesize that improved neonatal resuscitation in the delivery room may be partly responsible for the decrease. In premature children the decline was not significant in this time period, but has been dramatically decreasing in the years before the time period here analysed.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Paediatric Neurology
Vol/bind23
Nummer1
Sider (fra-til)94-101
Antal sider8
ISSN1090-3798
DOI
StatusUdgivet - 1 jan. 2019

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