Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Nicoline Hemager, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark
  • ,
  • Jens Richardt Møllegaard Jepsen, Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research
  • ,
  • Anne Amalie Elgaard Thorup, Research Unit at Child and Adolescent Mental Health Center and Research Unit at Mental Health Center Copenhagen, Københavns Universitet, Mental Health Centre Copenhagen, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Camilla Christiani, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark
  • ,
  • Ditte Ellersgaard, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark
  • ,
  • Katrine Søborg Spang, Centre for Child and Adolescent Mental Health
  • ,
  • Birgitte Klee Burton, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark
  • ,
  • Maja Gregersen, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark
  • ,
  • Aja Neergaard Greve
  • Ditte Lou Gantriis
  • Ole Mors
  • Merete Nordentoft, Københavns Universitet
  • ,
  • Kerstin J Plessen, Center for BioMedical Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

BACKGROUND: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia.

METHODS: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated.

RESULTS: Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups.

LIMITATIONS: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort.

CONCLUSIONS: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.

OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind281
Sider (fra-til)609-617
Antal sider9
ISSN0165-0327
DOI
StatusUdgivet - feb. 2021

Se relationer på Aarhus Universitet Citationsformater

ID: 206007950