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Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden

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Death of a child and the risk of atrial fibrillation : a nationwide cohort study in Sweden. / Wei, Dang; Olofsson, Tristan; Chen, Hua; Janszky, Imre; Fang, Fang; Ljung, Rickard; Yu, Yongfu; Li, Jiong; László, Krisztina D.

I: European Heart Journal, Bind 42, Nr. 15, 04.2021, s. 1489-1495.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Wei, D, Olofsson, T, Chen, H, Janszky, I, Fang, F, Ljung, R, Yu, Y, Li, J & László, KD 2021, 'Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden', European Heart Journal, bind 42, nr. 15, s. 1489-1495. https://doi.org/10.1093/eurheartj/ehaa1084

APA

Wei, D., Olofsson, T., Chen, H., Janszky, I., Fang, F., Ljung, R., Yu, Y., Li, J., & László, K. D. (2021). Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden. European Heart Journal, 42(15), 1489-1495. https://doi.org/10.1093/eurheartj/ehaa1084

CBE

Wei D, Olofsson T, Chen H, Janszky I, Fang F, Ljung R, Yu Y, Li J, László KD. 2021. Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden. European Heart Journal. 42(15):1489-1495. https://doi.org/10.1093/eurheartj/ehaa1084

MLA

Vancouver

Wei D, Olofsson T, Chen H, Janszky I, Fang F, Ljung R o.a. Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden. European Heart Journal. 2021 apr;42(15):1489-1495. https://doi.org/10.1093/eurheartj/ehaa1084

Author

Wei, Dang ; Olofsson, Tristan ; Chen, Hua ; Janszky, Imre ; Fang, Fang ; Ljung, Rickard ; Yu, Yongfu ; Li, Jiong ; László, Krisztina D. / Death of a child and the risk of atrial fibrillation : a nationwide cohort study in Sweden. I: European Heart Journal. 2021 ; Bind 42, Nr. 15. s. 1489-1495.

Bibtex

@article{6f33cb9e365e4a6dae521d7b7656822b,
title = "Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden",
abstract = "AIMS: The role of psychological stress in the aetiology of atrial fibrillation (AF) is unclear. The death of a child is one of the most severe sources of stress. We aimed to investigate whether the death of a child is associated with an increased risk of AF.METHODS AND RESULTS: We studied parents with children born during 1973-2014 included the Swedish Medical Birth Register (n = 3 924 237). Information on death of a child, AF and socioeconomic, lifestyle and health-related covariates was obtained through linkage to nationwide population and health registers. We examined the link between death of a child and AF risk using Poisson regression. Parents who lost a child had a 15% higher risk of AF than unexposed parents [incidence rate ratio (IRR) and 95% confidence intervals (CI): 1.15 (1.10-1.20)]. An increased risk of AF was observed not only if the child died due to cardiovascular causes [IRR (95% CI): 1.35 (1.17-1.56)], but also in case of deaths due to other natural [IRR (95% CI): 1.15 (1.09-1.21)] or unnatural [IRR (95% CI): 1.10 (1.02-1.19)] causes. The risk of AF was highest in the 1st week after the loss [IRR (95% CI): 2.87 (1.44-5.75)] and remained 10-40% elevated on the long term.CONCLUSIONS: Death of a child was associated with a modestly increased risk of AF. Our finding that an increased risk was observed also after loss of a child due to unnatural deaths suggests that stress-related mechanisms may also be implicated in the development of AF.",
keywords = "Atrial fibrillation, Bereavement, Death of a child, Psychological stress",
author = "Dang Wei and Tristan Olofsson and Hua Chen and Imre Janszky and Fang Fang and Rickard Ljung and Yongfu Yu and Jiong Li and L{\'a}szl{\'o}, {Krisztina D}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.",
year = "2021",
month = apr,
doi = "10.1093/eurheartj/ehaa1084",
language = "English",
volume = "42",
pages = "1489--1495",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "15",

}

RIS

TY - JOUR

T1 - Death of a child and the risk of atrial fibrillation

T2 - a nationwide cohort study in Sweden

AU - Wei, Dang

AU - Olofsson, Tristan

AU - Chen, Hua

AU - Janszky, Imre

AU - Fang, Fang

AU - Ljung, Rickard

AU - Yu, Yongfu

AU - Li, Jiong

AU - László, Krisztina D

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

PY - 2021/4

Y1 - 2021/4

N2 - AIMS: The role of psychological stress in the aetiology of atrial fibrillation (AF) is unclear. The death of a child is one of the most severe sources of stress. We aimed to investigate whether the death of a child is associated with an increased risk of AF.METHODS AND RESULTS: We studied parents with children born during 1973-2014 included the Swedish Medical Birth Register (n = 3 924 237). Information on death of a child, AF and socioeconomic, lifestyle and health-related covariates was obtained through linkage to nationwide population and health registers. We examined the link between death of a child and AF risk using Poisson regression. Parents who lost a child had a 15% higher risk of AF than unexposed parents [incidence rate ratio (IRR) and 95% confidence intervals (CI): 1.15 (1.10-1.20)]. An increased risk of AF was observed not only if the child died due to cardiovascular causes [IRR (95% CI): 1.35 (1.17-1.56)], but also in case of deaths due to other natural [IRR (95% CI): 1.15 (1.09-1.21)] or unnatural [IRR (95% CI): 1.10 (1.02-1.19)] causes. The risk of AF was highest in the 1st week after the loss [IRR (95% CI): 2.87 (1.44-5.75)] and remained 10-40% elevated on the long term.CONCLUSIONS: Death of a child was associated with a modestly increased risk of AF. Our finding that an increased risk was observed also after loss of a child due to unnatural deaths suggests that stress-related mechanisms may also be implicated in the development of AF.

AB - AIMS: The role of psychological stress in the aetiology of atrial fibrillation (AF) is unclear. The death of a child is one of the most severe sources of stress. We aimed to investigate whether the death of a child is associated with an increased risk of AF.METHODS AND RESULTS: We studied parents with children born during 1973-2014 included the Swedish Medical Birth Register (n = 3 924 237). Information on death of a child, AF and socioeconomic, lifestyle and health-related covariates was obtained through linkage to nationwide population and health registers. We examined the link between death of a child and AF risk using Poisson regression. Parents who lost a child had a 15% higher risk of AF than unexposed parents [incidence rate ratio (IRR) and 95% confidence intervals (CI): 1.15 (1.10-1.20)]. An increased risk of AF was observed not only if the child died due to cardiovascular causes [IRR (95% CI): 1.35 (1.17-1.56)], but also in case of deaths due to other natural [IRR (95% CI): 1.15 (1.09-1.21)] or unnatural [IRR (95% CI): 1.10 (1.02-1.19)] causes. The risk of AF was highest in the 1st week after the loss [IRR (95% CI): 2.87 (1.44-5.75)] and remained 10-40% elevated on the long term.CONCLUSIONS: Death of a child was associated with a modestly increased risk of AF. Our finding that an increased risk was observed also after loss of a child due to unnatural deaths suggests that stress-related mechanisms may also be implicated in the development of AF.

KW - Atrial fibrillation

KW - Bereavement

KW - Death of a child

KW - Psychological stress

UR - http://www.scopus.com/inward/record.url?scp=85104369779&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehaa1084

DO - 10.1093/eurheartj/ehaa1084

M3 - Journal article

C2 - 33515041

VL - 42

SP - 1489

EP - 1495

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 15

ER -