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Dealing with pervasive transcription

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  • Torben Heick Jensen
  • Alain Jacquier, Institut Pasteur, CNRS–UMR 3525, Unité de Génétique des Interactions Macromoléculaires
  • ,
  • Domenico Libri, CNRS–UPR 3404 Centre de Génétique Moléculaire, 91190 Gif-Sur-Yvette
Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly found RNAs have functions and how many are byproducts of functional, or spurious, transcription events. Cells control the accumulation of many opportunistic transcripts by limiting their synthesis and by provoking their early transcription termination and decay. In this review, we use S. cerevisiae and mammalian cells as models to discuss the circumstances by which pervasive transcripts are produced and turned over. This ultimately relates to the likelihood, and potential mechanism, of molecular function.
TidsskriftMolecular Cell
Sider (fra-til)473-484
Antal sider12
StatusUdgivet - 21 nov. 2013

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