Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study

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DOI

  • Jakob H. von Stemann, Rigshospitalet
  • ,
  • Ole B. Pedersen, Næstved Sygehus
  • ,
  • Henrik Hjalgrim, Statens Serum Institut, Rigshospitalet
  • ,
  • Christian Erikstrup
  • Henrik Ullum, Rigshospitalet
  • ,
  • Lise W. Thørner, Rigshospitalet
  • ,
  • Margit Ah Larsen, Rigshospitalet
  • ,
  • Kristoffer S. Burgdorf, Rigshospitalet
  • ,
  • Erik Sørensen, Rigshospitalet
  • ,
  • Morten B. Hansen, Rigshospitalet
  • ,
  • Sisse R. Ostrowski, Rigshospitalet

The presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results were linked to data from the Danish National Prescription Registry. The filing of an antimicrobial prescription following c-aAb measurement was used as a proxy for impaired immunocompetence. We found that c-aAb against pro-inflammatory cytokines IFNα and GM-CSF tended to associate with increased risk of prescription filings in women, whereas antibodies against anti-inflammatory IL-10 were associated with a lower predicted risk of antimicrobial prescriptions, as well as higher self-perceived health scores. We also observed an association of cumulative c-aAb presence with prescription risk. Our data show that cytokine autoantibodies in healthy individuals associate with various proxies for immunomodulation, with the exact association dependent on the pattern of pro- or anti-inflammatory cytokines targeted. This suggests that c-aAb may express cytokine-modulatory properties in healthy individuals and may be critical to further investigate as biomarkers of immunodeficiency.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Immunology
Vol/bind40
Nummer2
Sider (fra-til)367-377
Antal sider11
ISSN0271-9142
DOI
StatusUdgivet - feb. 2020

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