Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division

J E Celis; Peder Madsen; A Celis; H V Nielsen; B Gesser

Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division

J E Celis, Peder Madsen, A Celis, H V Nielsen, B Gesser

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

185 Citationer (Scopus)

Abstract

Cyclin, also known as PCNA or the auxiliary protein of mammalian DNA polymerase delta, is a stable cell cycle regulated (synthesized mainly in S-phase) nuclear protein of apparent Mr 36,000 whose rate of synthesis correlates directly with the proliferative state of normal cultured cells and tissues. Cyclin (PCNA) is absent or present in very low amounts in normal non-dividing cells and tissues, but it is synthesized in variable amounts by proliferating cells of both normal and transformed origin. All available information indicates that this ubiquitous and tightly regulated DNA replication protein is a central component of the pathway(s) leading to DNA replication and cell division.

Originalsprog	Engelsk
Tidsskrift	FEBS Letters
Vol/bind	220
Nummer	1
Sider (fra-til)	1-7
Antal sider	7
ISSN	0014-5793
Status	Udgivet - 10 aug. 1987

Citationsformater

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title = "Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division",

abstract = "Cyclin, also known as PCNA or the auxiliary protein of mammalian DNA polymerase delta, is a stable cell cycle regulated (synthesized mainly in S-phase) nuclear protein of apparent Mr 36,000 whose rate of synthesis correlates directly with the proliferative state of normal cultured cells and tissues. Cyclin (PCNA) is absent or present in very low amounts in normal non-dividing cells and tissues, but it is synthesized in variable amounts by proliferating cells of both normal and transformed origin. All available information indicates that this ubiquitous and tightly regulated DNA replication protein is a central component of the pathway(s) leading to DNA replication and cell division.",

keywords = "Animals, Cell Division, Cell Transformation, Neoplastic, DNA Polymerase III, DNA Replication, DNA-Directed DNA Polymerase, Humans, Nucleoproteins, Proliferating Cell Nuclear Antigen",

author = "Celis, {J E} and Peder Madsen and A Celis and Nielsen, {H V} and B Gesser",

year = "1987",

month = aug,

day = "10",

language = "English",

volume = "220",

pages = "1--7",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division

AU - Celis, J E

AU - Madsen, Peder

AU - Celis, A

AU - Nielsen, H V

AU - Gesser, B

PY - 1987/8/10

Y1 - 1987/8/10

N2 - Cyclin, also known as PCNA or the auxiliary protein of mammalian DNA polymerase delta, is a stable cell cycle regulated (synthesized mainly in S-phase) nuclear protein of apparent Mr 36,000 whose rate of synthesis correlates directly with the proliferative state of normal cultured cells and tissues. Cyclin (PCNA) is absent or present in very low amounts in normal non-dividing cells and tissues, but it is synthesized in variable amounts by proliferating cells of both normal and transformed origin. All available information indicates that this ubiquitous and tightly regulated DNA replication protein is a central component of the pathway(s) leading to DNA replication and cell division.

AB - Cyclin, also known as PCNA or the auxiliary protein of mammalian DNA polymerase delta, is a stable cell cycle regulated (synthesized mainly in S-phase) nuclear protein of apparent Mr 36,000 whose rate of synthesis correlates directly with the proliferative state of normal cultured cells and tissues. Cyclin (PCNA) is absent or present in very low amounts in normal non-dividing cells and tissues, but it is synthesized in variable amounts by proliferating cells of both normal and transformed origin. All available information indicates that this ubiquitous and tightly regulated DNA replication protein is a central component of the pathway(s) leading to DNA replication and cell division.

KW - Animals

KW - Cell Division

KW - Cell Transformation, Neoplastic

KW - DNA Polymerase III

KW - DNA Replication

KW - DNA-Directed DNA Polymerase

KW - Humans

KW - Nucleoproteins

KW - Proliferating Cell Nuclear Antigen

M3 - Review

C2 - 2886367

SN - 0014-5793

VL - 220

SP - 1

EP - 7

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division

Abstract

Fingeraftryk

Citationsformater