Cut to the chase-Regulating translation through RNA cleavage

Nicholas Sofos; Kehan Xu; Emil Dedic; Ditlev E. Brodersen

doi:10.1016/j.biochi.2015.01.009

Cut to the chase-Regulating translation through RNA cleavage

Nicholas Sofos, Kehan Xu, Emil Dedic, Ditlev E. Brodersen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

Originalsprog	Engelsk
Tidsskrift	Biochimie
Vol/bind	114
Sider (fra-til)	10-17
Antal sider	8
ISSN	0300-9084
DOI	https://doi.org/10.1016/j.biochi.2015.01.009
Status	Udgivet - jul. 2015

Adgang til dokumentet

10.1016/j.biochi.2015.01.009

Citationsformater

@article{9208c309e8cb40248d5f213e9a1342ee,

title = "Cut to the chase-Regulating translation through RNA cleavage",

abstract = "Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.",

author = "Nicholas Sofos and Kehan Xu and Emil Dedic and Brodersen, {Ditlev E.}",

note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",

year = "2015",

month = jul,

doi = "10.1016/j.biochi.2015.01.009",

language = "English",

volume = "114",

pages = "10--17",

journal = "Biochimie",

issn = "0300-9084",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Cut to the chase-Regulating translation through RNA cleavage

AU - Sofos, Nicholas

AU - Xu, Kehan

AU - Dedic, Emil

AU - Brodersen, Ditlev E.

PY - 2015/7

Y1 - 2015/7

N2 - Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

AB - Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

U2 - 10.1016/j.biochi.2015.01.009

DO - 10.1016/j.biochi.2015.01.009

M3 - Journal article

C2 - 25633441

SN - 0300-9084

VL - 114

SP - 10

EP - 17

JO - Biochimie

JF - Biochimie

ER -

Cut to the chase-Regulating translation through RNA cleavage

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater