Curcumin mitigates Aβ33-42 fibril-induced neuronal injury in the hippocampus

Ziyu Chen; Dan Xia; Xiaoteng Liang; Qian Liu; Jianwei Li; Qiang Li; Mingdong Dong

doi:10.1016/j.mtphys.2024.101436

Curcumin mitigates Aβ_33-42 fibril-induced neuronal injury in the hippocampus

Ziyu Chen, Dan Xia^*, Xiaoteng Liang, Qian Liu, Jianwei Li, Qiang Li^*, Mingdong Dong^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

The targeted removal of Aβ_33-42 accumulation in vivo emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ_33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ_33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ_33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.

Originalsprog	Engelsk
Artikelnummer	101436
Tidsskrift	Materials Today Physics
Vol/bind	44
ISSN	2542-5293
DOI	https://doi.org/10.1016/j.mtphys.2024.101436
Status	Udgivet - maj 2024

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10.1016/j.mtphys.2024.101436

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Citationsformater

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title = "Curcumin mitigates Aβ33-42 fibril-induced neuronal injury in the hippocampus",

abstract = "The targeted removal of Aβ33-42 accumulation in vivo emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.",

keywords = "Atomic force microscopy, Aβ fibrils, Cell injury model, Curcumin, Mechanical properties",

author = "Ziyu Chen and Dan Xia and Xiaoteng Liang and Qian Liu and Jianwei Li and Qiang Li and Mingdong Dong",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = may,

doi = "10.1016/j.mtphys.2024.101436",

language = "English",

volume = "44",

journal = "Materials Today Physics",

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TY - JOUR

T1 - Curcumin mitigates Aβ33-42 fibril-induced neuronal injury in the hippocampus

AU - Chen, Ziyu

AU - Xia, Dan

AU - Liang, Xiaoteng

AU - Liu, Qian

AU - Li, Jianwei

AU - Li, Qiang

AU - Dong, Mingdong

PY - 2024/5

Y1 - 2024/5

N2 - The targeted removal of Aβ33-42 accumulation in vivo emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.

AB - The targeted removal of Aβ33-42 accumulation in vivo emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.

KW - Atomic force microscopy

KW - Aβ fibrils

KW - Cell injury model

KW - Curcumin

KW - Mechanical properties

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U2 - 10.1016/j.mtphys.2024.101436

DO - 10.1016/j.mtphys.2024.101436

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SN - 2542-5293

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JO - Materials Today Physics

JF - Materials Today Physics

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