Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish

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The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97Å) and adopts an overall globular shape. Two antiparallel β-sheets form a central β-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures
OriginalsprogEngelsk
TidsskriftProteins: Structure, Function, and Bioinformatics
Vol/bind80
Nummer6
Sider (fra-til)1694-1698
Antal sider5
ISSN0887-3585
DOI
StatusUdgivet - jun. 2012

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