CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients

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CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients. / Drago, Antonio; Monti, Barbara; De Ronchi, Diana et al.

I: Psychiatry investigation, Bind 12, Nr. 1, 01.2015, s. 118-24.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Drago, A, Monti, B, De Ronchi, D & Serretti, A 2015, 'CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients', Psychiatry investigation, bind 12, nr. 1, s. 118-24. https://doi.org/10.4306/pi.2015.12.1.118

APA

Drago, A., Monti, B., De Ronchi, D., & Serretti, A. (2015). CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients. Psychiatry investigation, 12(1), 118-24. https://doi.org/10.4306/pi.2015.12.1.118

CBE

Drago A, Monti B, De Ronchi D, Serretti A. 2015. CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients. Psychiatry investigation. 12(1):118-24. https://doi.org/10.4306/pi.2015.12.1.118

MLA

Vancouver

Drago A, Monti B, De Ronchi D, Serretti A. CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients. Psychiatry investigation. 2015 jan.;12(1):118-24. https://doi.org/10.4306/pi.2015.12.1.118

Author

Drago, Antonio ; Monti, Barbara ; De Ronchi, Diana et al. / CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients. I: Psychiatry investigation. 2015 ; Bind 12, Nr. 1. s. 118-24.

Bibtex

@article{4f756559195943aea461214503e0ec60,
title = "CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients",
abstract = "OBJECTIVE: A relevant part of the social and personal burden caused by Bipolar Disorder (BD) is related to depressive phases. Authors investigated the genetic impact of a set of variations located in CRY1, a gene involved in the control of the circadian rhythms, towards depressive episodes in a sample of bipolar patients from the STEP-BD sample. As a secondary analysis, CYR1 variations were analyzed as predictors of sleep disruption.METHODS: 654 bipolar patients were included in the analysis. Data were available genome-wide. The part of the genome coding for the CRY1 was imputed and pruned according to standards in the field. 7 SNPs were available for the analysis. A correction for multitesting was applied and we had sufficient power (0.80) to detect a small-medium effect size (0.22) between two allelic frequencies each one represented by at least 300 subjects.RESULTS: Intronic rs10861688 was associated with the number of depressive events corrected for the times patients were assessed during the period of observation. In particular, AA subjects (n=21) had 4.46±3.15 events, AG (n=141) had 3.08±3.17 and GG (n=342) 2.65±2.97 (p=0.0048, beta=-0.22). No other significant associations were reported.CONCLUSION: We bring further evidence that genes involved in the regulation of circadian rhythms may be relevant to depressive bipolar phases. Independent confirmation analyses are mandatory.",
author = "Antonio Drago and Barbara Monti and {De Ronchi}, Diana and Alessandro Serretti",
year = "2015",
month = jan,
doi = "10.4306/pi.2015.12.1.118",
language = "English",
volume = "12",
pages = "118--24",
journal = "Psychiatry investigation",
issn = "1738-3684",
publisher = "Korean Neuropsychiatric Association",
number = "1",

}

RIS

TY - JOUR

T1 - CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients

AU - Drago, Antonio

AU - Monti, Barbara

AU - De Ronchi, Diana

AU - Serretti, Alessandro

PY - 2015/1

Y1 - 2015/1

N2 - OBJECTIVE: A relevant part of the social and personal burden caused by Bipolar Disorder (BD) is related to depressive phases. Authors investigated the genetic impact of a set of variations located in CRY1, a gene involved in the control of the circadian rhythms, towards depressive episodes in a sample of bipolar patients from the STEP-BD sample. As a secondary analysis, CYR1 variations were analyzed as predictors of sleep disruption.METHODS: 654 bipolar patients were included in the analysis. Data were available genome-wide. The part of the genome coding for the CRY1 was imputed and pruned according to standards in the field. 7 SNPs were available for the analysis. A correction for multitesting was applied and we had sufficient power (0.80) to detect a small-medium effect size (0.22) between two allelic frequencies each one represented by at least 300 subjects.RESULTS: Intronic rs10861688 was associated with the number of depressive events corrected for the times patients were assessed during the period of observation. In particular, AA subjects (n=21) had 4.46±3.15 events, AG (n=141) had 3.08±3.17 and GG (n=342) 2.65±2.97 (p=0.0048, beta=-0.22). No other significant associations were reported.CONCLUSION: We bring further evidence that genes involved in the regulation of circadian rhythms may be relevant to depressive bipolar phases. Independent confirmation analyses are mandatory.

AB - OBJECTIVE: A relevant part of the social and personal burden caused by Bipolar Disorder (BD) is related to depressive phases. Authors investigated the genetic impact of a set of variations located in CRY1, a gene involved in the control of the circadian rhythms, towards depressive episodes in a sample of bipolar patients from the STEP-BD sample. As a secondary analysis, CYR1 variations were analyzed as predictors of sleep disruption.METHODS: 654 bipolar patients were included in the analysis. Data were available genome-wide. The part of the genome coding for the CRY1 was imputed and pruned according to standards in the field. 7 SNPs were available for the analysis. A correction for multitesting was applied and we had sufficient power (0.80) to detect a small-medium effect size (0.22) between two allelic frequencies each one represented by at least 300 subjects.RESULTS: Intronic rs10861688 was associated with the number of depressive events corrected for the times patients were assessed during the period of observation. In particular, AA subjects (n=21) had 4.46±3.15 events, AG (n=141) had 3.08±3.17 and GG (n=342) 2.65±2.97 (p=0.0048, beta=-0.22). No other significant associations were reported.CONCLUSION: We bring further evidence that genes involved in the regulation of circadian rhythms may be relevant to depressive bipolar phases. Independent confirmation analyses are mandatory.

U2 - 10.4306/pi.2015.12.1.118

DO - 10.4306/pi.2015.12.1.118

M3 - Journal article

C2 - 25670954

VL - 12

SP - 118

EP - 124

JO - Psychiatry investigation

JF - Psychiatry investigation

SN - 1738-3684

IS - 1

ER -