COVER FIGURE in Nucleic Acids Research (Volume 39, Issue 9) entitled "The involvement of the nuclear-encoded human 2'-phosphodiesterase in mitochondrial RNA turnover"

Publikation: AndetAndet bidragForskning

  • Jesper Buchhave Poulsen, Danmark
  • Molekylærbiologisk Institut
(English) Cover: The involvement of the nuclear-encoded human 2'-phosphodiesterase (2'-PDE) in mitochondrial RNA turnover. The 2'-PDE precursor (upper left corner) gets directed into the mitochondrial matrix by an N-terminal mitochondrial signaling peptide (blue). Inside the matrix, this signaling peptide is cleaved-off (see magnification in lower left corner), and the 2'-PDE folded to generate a catalytically active protein actively degrading RNA (see magnification in upper right corner). Liberated ribonucleotide monophosphate products (A, G, C and U) are indicated by color-coded boxes and the remaining RNA by a curved line. The Exonuclease-Endonuclease-Phosphatase (EEP) nuclease motif of 2'-PDE, believed to include the active site is red.
OriginalsprogEngelsk
Udgivelsesårjan. 2011
UdgivelsesstedGreat Clarendon Street, Oxford, OX2 6DP, UK
UdgiverOxford University Press
UdgaveIssue 9
Vol/bindVolume 39
Antal sider1
ISBN (Trykt)(ISSN) 0305-1048
ISBN (Elektronisk)(ISSN) 1362-4962
StatusUdgivet - jan. 2011

Bibliografisk note

Denne Forside Figur knytter sig til artiklen: Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover, som også er en del af tidsskriftet, og som er forfattet af undertegnede med flere.

Artiklen har følgende detalje-oplysninger: Nucl. Acids Res. (2011) 39(9): 3754-3770 first published online January 17, 2011 doi:10.1093/nar/gkq1282

    Forskningsområder

  • 2'-phosphodiesterase, mitokondrier, exoribonuklease, RNA omsætning

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