Cost-effectiveness analysis of sacral nerve stimulation as treatment for severe irritable bowel syndrome

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AIM: Early results from sacral nerve stimulation (SNS) for severe irritable bowel syndrome (IBS) are promising but estimates of cost-effectiveness are lacking. Our object was to perform a cost-effectiveness analysis for SNS as an alternative to no treatment of IBS.

METHOD: This retrospective analysis was based on the results from a randomized controlled crossover study with a cost-utility analysis performed on patient-level data and modelling of censored data over a projected period of time of up to 20 years. The analysis was conducted on an intention-to-treat approach. For estimation of the uncertainty of the incremental cost-effectiveness ratio a bias corrected bootstrap analysis was performed.

RESULTS: Cost-effectiveness was not reached for 4 years after permanent implantation (£31 270 per quality-adjusted life years), which was the upper limit for patient follow-up, but our data imply a cost-effectiveness from a 7-year perspective onwards.

CONCLUSION: The study indicates the SNS treatment for IBS is cost effective from a 7-year perspective onwards.

OriginalsprogEngelsk
TidsskriftColorectal Disease
Vol/bind18
Nummer1
Sider (fra-til)O30-36
Antal sider7
ISSN1462-8910
DOI
StatusUdgivet - jan. 2016

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