Coronary volume to left ventricular mass ratio in patients with diabetes mellitus

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DOI

  • Jurrien H Kuneman, Leiden University
  • ,
  • Mohammed El Mahdiui, Leiden University
  • ,
  • Alexander R van Rosendael, Leiden University
  • ,
  • Inge J van den Hoogen, Leiden University
  • ,
  • Manesh R Patel, Duke University
  • ,
  • Bjarne Linde Nørgaard
  • Timothy A Fairbairn, Liverpool Business Sch, Liverpool John Moores University, University of Liverpool
  • ,
  • Koen Nieman, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • ,
  • Takashi Akasaka, Wakayama Medical University, Wakayama, Japan.
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  • Daniel S Berman, Cedars Sinai Heart Institute
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  • Lynne M Hurwitz Koweek, Duke University
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  • Gianluca Pontone, Centro Cardiologico Monzino, Milan
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  • Tomohiro Kawasaki, Qatar Cardiovascular Research Center
  • ,
  • Niels Peter Rønnow Sand, Syddansk Universitet
  • ,
  • Jesper M Jensen
  • Tetsuya Amano, Aichi Medical University, Aichi
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  • Michael Poon, Department of Noninvasive Cardiac Imaging, Northwell Health, New York, New York.
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  • Kristian A Øvrehus, Syddansk Universitet
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  • Jeroen Sonck, Univ Naples Federico II, University of Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci
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  • Mark G Rabbat, Loyola Univ Chicago, Loyola University Chicago, Dept Urol
  • ,
  • Bernard De Bruyne, Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
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  • Campbell Rogers, Heartflow Inc.
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  • Hitoshi Matsuo, Gifu Heart Center, Gifu, Japan.
  • ,
  • Jeroen J Bax, Leiden University
  • ,
  • Jonathon A Leipsic, St. Paul's Hospital Taoyuan
  • ,
  • Juhani Knuuti, Leiden University

BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.

METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.

RESULTS: Of the 3053 patients (age 66 ​± ​10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ​± ​940 ​mm3 vs. 3040 ​± ​970 ​mm3, p ​< ​0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ​± ​33 ​g vs. 122 ​± ​32 ​g, p ​= ​0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ​± ​6.8 ​mm3/g vs. 25.7 ​± ​7.5 ​mm3/g, p ​< ​0.0001). Among subjects with obstructive CAD (n ​= ​2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ​± ​6.7 ​mm3/g vs. 25.0 ​± ​7.3 ​mm3/g, p ​< ​0.0001 and 25.6 ​± ​6.9 ​mm3/g vs. 27.3 ​± ​7.6 ​mm3/g, respectively, p ​= ​0.006).

CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Computed Tomography
ISSN1934-5925
DOI
StatusE-pub ahead of print - 1 feb. 2022

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Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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